EFFECT OF NICARDIPINE, A CALCIUM ANTAGONIST, ON INDUCTION OF PEROXISOMAL ENZYMES BY DEHYDROEPIANDROSTERONE SULFATE IN CULTURED RAT HEPATOCYTES
スポンサーリンク
概要
- 論文の詳細を見る
We examined the effect of nicardipine, a calcium antagonist, on the induction of peroxisomal enzymes, such as acyl-CoA oxidase and carnitine acetyltransferase, by dehydroepiandrosterone sulfate (DHEAS) and clofibric acid (CPIB), in primary cultured rat hepatocytes. Peroxisomal β-oxidation and carnitine acetyltransferase activities were increased 11- and 20-fold, respectively, after 5 days of treatment with DHEAS (40 μM). However, 60 μM nicardipine significantly suppressed the induction of both of these activities by DHEAS to about 2-fold that of the control. This suppression was found to be both dose- and time-dependent. Immunoblot and Northern blot analyses of acyl-CoA oxidase revealed that suppression by nicardipine of the induction of peroxisomal β-oxidation activity would be responsible for an increase in the amount of mRNA. In addition, the manner in which nicardipine suppressed the induction of peroxisomal β-oxidation and carnitine acetyltransferase activity, was similar to that of clofibric acid. These findings suggest that in the calcium-dependent pathway, the mechanism for the induction of peroxisomal enzymes by DHEAS is basically the same as that by clofibric acid, a typical peroxisome proliferator. The present results also support our previous hypothesis that calcium may play an important role in the induction of these enzymes by peroxisome proliferators.
- 日本トキシコロジー学会の論文
- 1996-11-25
著者
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Tamura Hiroshi
Department of Cardiology, Juntendo University School of Medicine
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Yamada Junji
Department of Pharmacotherapeutics, School of Pharmacy, Tokyo University of Pharmacy and Life Scienc
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Zhang Hong
Department Of Nuclear Medicine Second Affiliated Hospital Of Zhejiang University School Of Medicine
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Yamada Junji
Dept. Clin. Biochem. Sch. Pharm. Sci. Tokyo College Of Pharmacy
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Yamada J
Takeda Chemical Industries Ltd. Tsukuba Jpn
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WATANABE Takafumi
Department of Clinical Biochemistry, Tokyo University of Pharmacy and Life Science
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SUGA Tetsuya
Department of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Scien
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Yamada Junji
Department Of Clinical Biochemistry School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Yamada Junji
Agrucultural Research Laboratories Agro Division Takeda Chemical Industries Ltd.
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Watanabe T
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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Takayama Hisako
Reproductive Pediatric And Infectious Science Yamaguchi University School Of Medicine
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Suga T
Dept. Clin. Biochem. Sch. Pharm. Sci. Tokyo College Of Pharmacy
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Suga Tetsuya
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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Suga Tetsuya
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Suga T
Department Of Clinical Biochemistry School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Tamura Hiroshi
Department Of Obstetrics And Gynecology Yamaguchi University Graduate School Of Medicine
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Tamura Hiroshi
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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Tamura H
Department Of Obstetrics And Gynecology Yamaguchi University Graduate School Of Medicine
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Watanabe Takafumi
Department Of Aerospace Engineering Osaka Prefecture University
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Zhang Hong
Department Of Biological Sciences Texas Tech University
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Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Zhang Hong
Department Of Clinical Biochemistry School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Tamura Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Niigata University
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TAMURA Hiroshi
Department of Mathematics, Faculty of Science Kanazawa University
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TAMURA Hiroshi
Department of Physics, Kanazawa University
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TAMURA Hiroshi
Department of Mathematics, Kanazawa University
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