Impact of Metabolic Syndrome on 10-Year Clinical Outcomes Among Patients With Acute Coronary Syndrome
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概要
- 論文の詳細を見る
Background: Metabolic syndrome (MetS) is a risk factor and prognosticator for ischemic heart disease, but its actual effect on long-term mortality after acute coronary syndrome (ACS) remains unknown. Methods and Results: All-cause death and cardiovascular death were investigated among patients with ACS upon admission who underwent complete revascularization by either percutaneous coronary intervention or bypass surgery between 1984 and 1992. MetS was defined according to the NCEP/ATPIII criteria modified for waist circumference. From among 1,836 patients who underwent complete revascularization during the study period, 384 (21.0%) with ACS were enrolled, of whom 163 (42.5%) had MetS. During a mean follow-up of 10.4 ±3.4 years, the total number of deaths was 83 (21.6%), of which 38 (9.9%) were from cardiovascular causes. Cox proportional hazard analysis revealed that MetS increased the risk of mortality by a ratio of 1.62 (95% confidence interval (CI) 1.01-2.59, P=0.046) and of cardiovascular death by 2.40 (95%CI 1.16-4.94, P=0.018) in patients with ACS. Conclusions: MetS is a powerful determinant of long-term all-cause and cardiovascular death after ACS. Furthermore, MetS and ACS might jointly exacerbate poor long-term outcomes. (Circ J 2009; 73: 1454 - 1458)
- 社団法人 日本循環器学会の論文
- 2009-07-20
著者
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DAIDA Hiroyuki
Department of Cardiology, Juntendo University School of Medicine
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Kudoh Takashi
Department Of Nuclear Medicine Kyoto University Faculty Of Medicine
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Kimura Takeshi
Kyoto University Hospital
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Kobayashi Takashi
Department Of Cardiology Kobe City Medical Center General Hospital
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Yokoyama Ken
Department Of Cardiovascular Medicine Juntendo University
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Matsuyama Koshi
Clinical Education Center Kumamoto University Hospital
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Kurita Takashi
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Miyauchi Katsumi
Department Of Cardiovascular Medicine Juntendo University
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Miyauchi Katsumi
Department Of Cardiology Juntendo University School Of Medicine
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Miyauchi Katsumi
Department Of Medicine Juntendo University School Of Medicine
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Daida Hiroyuki
Department Of Cardiology Juntendo University School Of Medicine
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Kajimoto Kan
Department of Cardiovascularsurgery, Juntendo University
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Dohi Tomotaka
Department of Cardiology, Juntendo University School of Medicine
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Kubota Naozumi
Department of Cardiology, Juntendo University School of Medicine
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Tamura Hiroshi
Department of Cardiology, Juntendo University School of Medicine
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Kojima Takahiko
Department of Cardiology, Juntendo University School of Medicine
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Kurata Takeshi
Department Of Cardiology Juntendo University School Of Medicine
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Kasai Takatoshi
Department Of Cardiology Juntendo University
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Kurita Takashi
The NATIVE
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Miyauchi Katsumi
Department Of Cardiovascular Medicine Juntendo University School Of Medicine
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Yokoyama Takayuki
Department Of Cardiology Juntendo University School Of Medicine
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Kobayashi Takashi
Department Of Cardiology National Cardiovascular Center
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Kajimoto Kan
Department Of Cardiology Juntendo University School Of Medicine
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Daida Hiroyuki
Department Of Cardiology
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Kawasumi Masahiko
Department Of Cardiology Juntendo University School Of Medicine
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Miyauchi Katsumi
Clinical Education Center Kumamoto University Hospital
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Kajimoto Kan
Department Of Cardiovascular Surgery Juntendo University
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Kudoh T
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Tanaka Keiji
Intensive And Cardiac Care Unit Nippon Medical School
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Kawasumi Masahiko
Department Of Medicine Metabolism And Endocrinology Juntendo University School Of Medicine
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Kawamura Teruhisa
Division Of Translational Research Kyoto Medical Center
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Kajimoto Kan
Department Of Cardiovascular Surgery Juntendo University School Of Medicine
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Tamura Hiroshi
Department Of Cardiovascular Medicine Juntendo University
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Daida Hiroyuki
Department Of Medicine Juntendo University School Of Medicine
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Tamita Koichi
Departmento Of Cardiology Kobe General Hospital
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Dohi Tomotaka
Department Of Cardiology Juntendo University School Of Medicine
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Kubota Naozumi
Department Of Cardiology Juntendo University School Of Medicine
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Kudoh Takashi
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Katoh Takao
Department Of Disease Control And Homeostasis Graduate School Of Medical Science Kanazawa University
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Miyauchi Katsumi
Division Of Cardiology Department Of Internal Medicine Juntendo University School Of Medicine
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TAMURA Hiroshi
Juntendo University Shizuoka Hospital
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Kimura Takeshi
Department Of Respiratory Medicine Otsu Red Cross Hospital
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Koyama Takashi
Cardiovascular Division Institute Of Clinical Medicine Graduate School Of Comprehensive Human Scienc
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Tamura Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Niigata University
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KIYOOKA Takahiko
Tokai University Hachioji Hospital
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Kojima Takahiko
Department of Cardiology, Juntendo University Izunagaoka Hospital
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Yokoyama Ken
Department of Cardiology, Juntendo University School of Medicine
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