Germ Cell Loss Induced by ^<12>C^<6+> Ion Irradiation in Young Female Mice

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概要

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• The ovaries of Kun-Ming strain mice (3 weeks) were irradiated with different doses of ^<12>C^<6+> ion in the Bragg peak or the plateau region. At lOth day after irradiation, ovarian and uterine weights were measured; normal and atretic (identified with the oocyte to be degenerating or absent) primordial, primary and preantral follicles were identified in the largest cross-section of each ovary. Percentage (%) of normal follicles of each developmental stage of oogenesis was calculated. The data showed that compared to controls, there was a dose-related decrease in percentage of normal follicles in each developmental stage. And the weights of ovary and uterus were also reduced with doses of irradiation. Moreover, these effects were much more significant in the Bragg peak region and the region close to the Bragg peak than in the beam's entrance (the plateau region). Radiosensitivity varied in different follicle maturation stages. Primordial follicles, which are thought to be extremely sensitive to ionizing irradiation, were reduced by 86.6%, while primary and preantral follicles reduced only by 72.5% and 61.8% respectively, by exposure with 6 Gy of ^<12>C^<6+> ion in the Bragg peak region and the region close to the Bragg peak. The data suggested that due to their optimal depth-dose distribution in the Bragg peak region, heavy ions are ones of the best particles for radiotherapy of tumors located next of vital organs or/and surrounded by normal tissues, especially radiosensitive tissues such as gonads.

• 日本放射線影響学会の論文
• 2006-06-30

著者

• Xie Yi

  Research Center For Heavy Ion Radiation Biology And Medicine Institute Of Modern Physics Chinese Aca

• Xie Yi

  Department Of Hematology Affiliated Huashan Hospital Fudan University

• Liu Bing

  Department Of Medical Physics Institute Of Modern Physics Chinese Academy Of Sciences

• Zhang Hong

  Department Of Nuclear Medicine Second Affiliated Hospital Of Zhejiang University School Of Medicine

• Zhang Hong

  Research Center For Heavy Ion Radiation Biology And Medicine Institute Of Modern Physics Chinese Aca

• Xie Yi

  Department Of Applied Chemistry School Of Chemical And Material Engineering Southern Yangtze Univers

• ZHANG Xu

  Department of Ophthalmology, Faculty of Medicine, Kyushu University

• Zhang Xu

  Department Of Pathology Lanzhou University

• DUAN XIN

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• ZHOU QINGMING

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• YUAN Zhigang

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• LI Xiaoda

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• LI Wenjian

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• MIN Fengling

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• Duan Xin

  Department Of Medical Physics Institute Of Modern Physics Chinese Academy Of Sciences

• Li Xiaoda

  Department Of Medical Physics Institute Of Modern Physics Chinese Academy Of Sciences

• Li Wenjian

  Department Of Medical Physics Institute Of Modern Physics Chinese Academy Of Sciences

• Min Fengling

  Department Of Medical Physics Institute Of Modern Physics Chinese Academy Of Sciences

• Yuan Zhigang

  Department Of Medical Physics Institute Of Modern Physics Chinese Academy Of Sciences

• Zhou Qingming

  Department Of Medical Physics Institute Of Modern Physics Chinese Academy Of Sciences

• Zhang Xu

  Department Of Automatic Measurement And Control The School Of Computer Science And Electrical Engine

• Zhang Hong

  Department Of Chemistry University Of British Colombia

• Zhang Hong

  Department Of Biological Sciences Texas Tech University

• Liu Bing

  Department Of Mathematics Hubei Normal University

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