Fischer Indolization and Its Related Compounds. XVIII. Formation of Four Unexpected Angular Benz [e] indoles on Fischer Indolization of Ethyl Phenylpyruvate 2-[(1,4-Dimethoxy-2-naphthyl) hydrazone]
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概要
- 論文の詳細を見る
The Fischer indolization of ethyl phenylpyruvate 2-[(1,4-dimethoxy-2-naphthyl) hydrazone] (2) with ethanolic hydrogen chloride gave four angular benz [e] indole products (ethyl 4-chloro-5-ethoxy-(14a), ethyl 4-chloro-5-methoxy-(14b), ethyl 5-ethoxy-(14c), and ethyl 5-methoxy-(14d)-1-phenyl-3H-benz [e] indole-2-carboxylates), instead of the anticipated linear benz [f] indole, ethyl 4,9-dimethoxy-3-phenyl-1H-benz [f] indole-2-carboxylate (3). Oxidation of these benz [e] indole derivatives (14b and 14d) with chromic acid in acetic acid provided an o-quinone derivative (15) which showed anti-viral activity in a preliminary biological test.
- 社団法人日本薬学会の論文
- 1983-12-25
著者
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石井 永
Faculty of Pharmaceutical Sciences, Chiba University
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渡辺 敏子
千葉大院薬
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渡辺 敏子
School Of Pharmaceutical Sciences Toho University
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石井 永
Faculty Of Pharmaceutical Sciences Chiba University
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Murakami Yukihisa
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Murakami Yukihisa
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)
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谷 昇平
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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谷 昇平
Faculty Of Pharmaceutical Sciences Chiba University
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Watanabe Toshifumi
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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鈴木 英治
School of Pharmaceutical Sciences, Toho University
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Watanabe T
Chiba Univ. Chiba Jpn
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Watanabe Toshihiro
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Ishii H
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Suzuki H
Tokyo Metropolitan Univ. Tokyo Jpn
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