Fischer Indolization of Ethyl Pyruvate 2-Bis(2-methoxyphenyl)hydrazone and New Insight into the Mechanism of Fischer Indolization.(Fischer Indolization and Its Related Compounds. XXVII)

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概要

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• In connection with studies on the direction of cyclization in the Fischer indolization of substituted diphenylhydrazones, the Fischer indolization of ethyl pyruvate 2-bis(2-methoxyphenyl)hydrazone (6) was carried out. The result showed that cyclization in Fischer indolization of diphenylhydrazone does not always proceed to the electron-richer nucleus, but depends on the conformation of the enehydrazine. Thus, the Fischer indolization should proceed via a [3,3] sigmatropic route, with an electronic effect.

• 公益社団法人日本薬学会の論文
• 1995-08-15

著者

• 渡辺 敏子

  School Of Pharmaceutical Sciences Toho University

• 大塚 朋子

  School Of Pharmaceutical Sciences Toho University

• 横山 祐作

  School of Pharmaceutical Sciences, Toho University

• 村上 泰興

  School of Pharmaceutical Sciences, Toho University

• Watanabe Toshifumi

  Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries

• 岩田 勉

  School of Pharmaceutical Sciences, Toho University

• 山田 優里子

  School of Pharmaceutical Sciences, Toho University

• Watanabe Toshihiro

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.

• 岩田 勉

  School Of Pharmaceutical Sciences Toho University

• Iwata Tsutomu

  School Of Pharmaceutical Sciences Toho University

• 村上 泰興

  東邦大・薬

• 村上 泰興

  School Of Pharmaceutical Science Toho University

• 横山 祐作

  東邦大学薬学部

• 山田 優里子

  School Of Pharmaceutical Sciences Toho University

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