A NEW GENERAL SYNTHETIC ROUTE FOR 1-SUBSITUTED 4-OXYGENATED β-CARBOLINES

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概要

• 論文の詳細を見る

• Two naturally occurring 1-substituted 4-methoxy-β-carboline (1b, c) weer synthesized from ethyl indole-2-carboxylate (5b) and its 1-benzyl derivative (5a), respectively. The synthesis routes involved elaboration of the ester group of 5a, b, cyclization of the substituent at the 2-position toward the 3-position of the indole nucleus, and functionalization at the 1-position of the β-carboline nucleus by a modified Reissert reaction. The β-carbolites (1b, c) thus prepared should be mother compounds for the synthesis of their congeners.

• 社団法人日本薬学会の論文
• 1991-08-25

著者

• 横山 祐作

  School of Pharmaceutical Sciences, Toho University

• 村上 泰興

  School of Pharmaceutical Sciences, Toho University

• 鈴木 英治

  School of Pharmaceutical Sciences, Toho University

• 宮城 智恵美

  School of Pharmaceutical Sciences, Toho University

• 村上 泰興

  東邦大・薬

• 村上 泰興

  School Of Pharmaceutical Science Toho University

• Suzuki H

  Tokyo Metropolitan Univ. Tokyo Jpn

• 宮城 智恵美

  School Of Pharmaceutical Sciences Toho University

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