Inhibition of D-Amino Acid Oxidase Activity by Antipsychotic Drugs Evaluated by a Fluorometric Assay Using D-Kynurenine as Substrate
スポンサーリンク
概要
- 論文の詳細を見る
A facile fluorometric assay using D-kynurenine as a substrate was utilized for evaluating the inhibition of D-amino acid oxidase (DAAO), which is one of the products of a susceptibility gene for schizophrenia, by commercial antipsychotic drugs, namely, chlorpromazine (CPZ), carbamazepine, sulpiride, quetiapine, and imipramine. CPZ inhibited DAAO (65.8 ± 13.2 μM, n = 3) as reported previously, and other drugs also inhibited DAAO activity. Among these, quetiapine had the smallest IC50 value (19.5 ± 2.60 μM, n = 3). The proposed assay can be useful for the evaluation or screening of DAAO-inhibitory drugs.
著者
-
横山 祐作
東邦大学薬学部
-
中林 萌
東邦大学薬学部 薬品分析学教室
-
横山 祐作
東邦大学薬学部 薬品製造学教室
-
岩佐 澄子
東邦大学薬学部 薬品分析学教室
-
田原 翔志
東邦大学薬学部 薬品分析学教室
-
宋 梓瑜
東邦大学薬学部 薬品分析学教室
-
福島 健
東邦大学薬学部 薬品分析学教室
関連論文
- Fischer Indolization of Variously ortho-Substituted Phenylhydrazones (Fischer Indolization and Its Related Compounds. XXV)
- 89(P02) 光学活性4-ブロモトリプトファンを利用した麦角アルカロイドChanoclavine-Iの全合成(ポスター発表の部)
- Synthetic Studies on Indoles and Related Compounds 50. Improved Synthesis of 7,9-Didecarboxymethoxathine
- Synthetic Studies of Indoles and Related Compounds. XXVIII. Intramolecular Vinylation of Pyrrole Derivatives Using Palladium : a New Synthetic Method for Substituted Indoles
- Synthetic Studies of Indoles and Related Compounds. XXVII. A New Synthesis of Crenatine from Ethyl Indole-2-carboxylate
- Fischer Indolization of Ethyl Pyruvate 2-Bis(2-methoxyphenyl)hydrazone and New Insight into the Mechanism of Fischer Indolization.(Fischer Indolization and Its Related Compounds. XXVII)
- New Synthetic Method for Dehydrotryptophan Derivatives. Synthetic Studies on Indoles and Related Compounds. XXXIV
- ライフサイエンス分野における産学連携 : 大学における知的財産と今後の展開について
- ピッツバーグの熱い日々
- 薬学におけるこれからの有機化学教育