β-Acylation of Ethyl Pyrrole-2-carboxylate by Friedel-Crafts Acylation : Scope and Limitations (Synthetic Studies on Indoles and Related Compounds. XXXVIII)

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概要

• 論文の詳細を見る

• The Friedel-Crafts acylation of ethyl pyrrole-2-carboxylate (3) was studied under several conditions using various Lewis acids and acyl chlorides. The acylation with various acyl chlorides in the presence of aluminum chloride gave exclusively ethyl 4-acylpyrrole-2-carboxylate (5), whereas weaker Lewis acids such as zinc chloride and boron trifluoride etherate gave a mixture of ethyl 4- and 5-acylpyrrole-2-carboxylates.

• 公益社団法人日本薬学会の論文
• 1996-01-15

著者

• 渡辺 敏子

  School Of Pharmaceutical Sciences Toho University

• Murakami Yukihisa

  富山大学和漢医薬学総合研究所 複合薬物薬理学

• Mukarami Yukihisa

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Murakami Yukihisa

  Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U

• Murakami Yukihisa

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)

• Watanabe Toshifumi

  Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries

• Watanabe T

  Chiba Univ. Chiba Jpn

• Watanabe Toshiko

  Faculty Of Pharmaceutical Sciences Chiba University

• Watanabe Toshiko

  Graduate School Of Pharmaceutical Sciences Chiba University

• Watanabe Toshihiro

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.

• Murakami Y

  Department Of Bioactive Molecules National Institute Of Infectious Diseases

• TANI Mayo

  Faculty of Pharmaceutical Sciences,Tokushima Bunri University

• Tani M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Nishiyama C

  School Of Pharmaceutical Sciences Toho University

• Hagiwara H

  School Of Pharmaceutical Sciences Toho University

• MURAKAMI Yasuoki

  School of Pharmaceutical Sciences, Toho University

• YOKOYAMA Yuusaku

  School of Pharmaceutical Sciences, Toho University

• TANI Masanobu

  School of Pharmaceutical Sciences, Toho University

• ARIYASU Takahiro

  School of Pharmaceutical Sciences, Toho University

• NISHIYAMA Chika

  School of Pharmaceutical Sciences, Toho University

• HAGIWARA Hiroko

  School of Pharmaceutical Sciences, Toho University

• WATANABE Toshiko

  School of Pharmaceutical Sciences, Toho University

• Yokoyama Y

  School Of Pharmaceutical Sciences Toho University

• Ariyasu Takahiro

  School Of Pharmaceutical Sciences Toho University

• Murakami Yasuoki

  School Of Pharmaceutical Sciences Toho University

• Yokoyama Yuusaku

  School of Pharmaceutical Science, Toho University

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