New Findings on the Hemetsberger-Knittel Reaction (Synthetic Studies on Indoles and Related Compounds. XLIII)

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概要

• 論文の詳細を見る

• In the Hemetsberger-Knittel reaction for indole synthesis, the intermediate ethyl 2-azido-3-hydroxy-3-aryl-propionate (4) was found to be formed in the reaction of arylaldehyde 1 with ethyl azidoacetate at a lower temperature (-30℃) as the main product, while only ethyl 2-azidocinnamate (2) is known to be formed at a higher temperature (0℃). It was also found that fluoride ion was effective for obtaining 4. Compound 4 was converted to 2 in good yield by treatment with SOCl_2/pyridine or SOCl_2/Et_3N. A trial application of this reaction to ketone is also described.

• 公益社団法人日本薬学会の論文
• 1997-11-15

著者

• Watanabe T

  Chiba Univ. Chiba Jpn

• WATANABE Toshiko

  Faculty of Pharmaceutical Sciences, Josai University

• Watanabe Toshiko

  Faculty Of Pharmaceutical Sciences Chiba University

• MURAKAMI Yasuoki

  School of Pharmaceutical Sciences, Toho University

• SUZUKI Hideharu

  School of Pharmaceutical Sciences, Toho University

• KOTAKE Nobuyo

  School of Pharmaceutical Sciences, Toho University

• TAKAHASHI Tomoko

  School of Pharmaceutical Sciences, Toho University

• TOYONARI Kiyono

  School of Pharmaceutical Sciences, Toho University

• OHNO Masami

  School of Pharmaceutical Sciences, Toho University

• TAKASE Kyoko

  School of Pharmaceutical Sciences, Toho University

• SUZUKI Takayuki

  School of Pharmaceutical Sciences, Toho University

• KONDO Kazuhiro

  School of Pharmaceutical Sciences, Toho University

• Suzuki Hideharu

  School Of Pharmaceutical Sciences Toho University

• Ohno M

  School Of Pharmaceutical Sciences Toho University

• Takase K

  School Of Pharmaceutical Sciences Toho University

• Kotake Nobuyo

  School Of Pharmaceutical Sciences Toho University

• Toyonari Kiyono

  School Of Pharmaceutical Sciences Toho University

• Murakami Yasuoki

  School Of Pharmaceutical Sciences Toho University

• Kondo Kazuhiro

  School Of Pharmaceutical Sciences Toho University

• Takahashi Tomoko

  School Of Pharmaceutical Sciences Toho University

• Suzuki Takayuki

  School Of Pharmaceutical Sciences Toho University

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