Total Synthesis of Optically Active Costaclavine (Synthetic Studies of Indoles and Related Compounds Part 48.)

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概要

• 論文の詳細を見る

• The first total synthesis of optically active costaclavine (18), an ergot alkaloid, was accomplished starting from methyl [4R-(Z)]-[4-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3,4-dihydro-1-[(4-methylphenyl)sulfonyl]-benz[cd]indol-5(1H)-ylidene]acetate (8), which was prepared by intramolecular cyclization of 1,1-dimethylethyl[1R-(E)]-[1-[[4-bromo-1-[(4-methylphenyl)-sulfonyl]-1H-indol-3-yl]methyl]-4-carbomethoxy-2-propenyl]methylcarbamate (7) according to the method we developed earlier during the course of the total synthesis of chanoclavine-I (9).

• 公益社団法人日本薬学会の論文
• 1999-11-15

著者

• YOKOYAMA Yuusaku

  School of Pharmaceutical Sciences, Toho University

• Yokoyama Y

  School Of Pharmaceutical Sciences Toho University

• Murakami Yasuoki

  School Of Pharmaceutical Sciences Toho University

• Kondo Kazuhiro

  School Of Pharmaceutical Sciences Toho University

• OSANAI Kumi

  School of Pharmaceutical Sciences, Toho University

• Osanai K

  Toho Univ. Chiba Jpn

• Yokoyama Yuusaku

  School of Pharmaceutical Science, Toho University

関連論文

• Substituent Effects in the Fischer Indolization of (2-Sulfonyloxyphenyl)-hydrazones (Fischer Indolization and Related Compounds . XXX)
• New Findings on the Hemetsberger-Knittel Reaction (Synthetic Studies on Indoles and Related Compounds. XLIII)
• β-Acylation of Ethyl Pyrrole-2-carboxylate by Friedel-Crafts Acylation : Scope and Limitations (Synthetic Studies on Indoles and Related Compounds. XXXVIII)
• New Strategy for Indole Synthesis from Ethyl Pyrrole-2-carboxylate (Synthetic Studies on Indoles and Related Compounds. XXXIX)
• Synthetic Utility of tert-Butyl Azidoacetate on the Hemetsberger-Knittel Reaction (Synthetic Studies of Indoles and Related Compounds Part 47)
• 2-Chloro-N, N-dibenzoylaniline : a Selective N-Benzoylating Reagent
• Total Synthesis of Optically Active Costaclavine (Synthetic Studies of Indoles and Related Compounds Part 48.)
• Synthesis of a Key Intermediate for the Preparation of FTY720 Analogs
• Synthesis of VIP-Lipopeptide using a New Linker to Modify Liposomes: Towards the Development of a Drug Delivery System for Active Targeting

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