Hydronaphthalenones and a Dihydroramulosin from the Endophytic Fungus PSU-N24
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概要
- 論文の詳細を見る
Three new hydronaphthalenone derivatives (1-3) and one new dihydroramulosin derivative (4), were isolated from the endophytic fungus PSU-N24 together with eight known compounds. Their structures were elucidated by spectroscopic methods. Griseofulvin (9) displayed strong antifungal activity against Microsporum gypseum SH-MU-4 with a minimum inhibitory concentration (MIC) value of 2μg/ml while all metabolites exhibited very weak antibacterial activity (MIC value≥128μg/ml) against Staphylococcus aureus, both standard and methicillin-resistant strains. 3-(2-Hydroxypropyl)benzene-1,2-diol (10) showed moderate antimalarial activity against Plasmodiun falciparum with an IC_<50> value of 6.68μg/ml. For antimycobacterial activity against Mycobacterium tuberculosis, compound 3 gave the best activity with the MIC value of 12.50μg/ml.
- 2008-12-01
著者
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SOMMART Ubonta
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Pr
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RUKACHAISIRIKUL Vatcharin
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Pr
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SUKPONDMA Yaowapa
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Pr
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PHONGPAICHIT Souwalak
Natural Products Research Center and Department of Microbiology, Faculty of Science, Prince of Songk
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SAKAYAROJ Jariya
National Center for Genetic Engineering and Biotechnology (BIOTEC)
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KIRTIKARA Kanyawim
National Center for Genetic Engineering and Biotechnology (BIOTEC)
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Phongpaichit Souwalak
Natural Products Research Center And Department Of Microbiology Faculty Of Science Prince Of Songkla
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Sakayaroj Jariya
タイ
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Kirtikara Kanyawim
タイ
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Kirtikara K
National Sci. And Technol. Dev. Agency (nstda) Bangkok Tha
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Kirtikara Kanyawim
National Center For Genetic Engineering And Biotechnology
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Sommart Ubonta
Department Of Chemistry And Center Of Excellence For Innovation In Chemistry Faculty Of Science Prin
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Sommart Ubonta
タイ
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Kirtikara Kanyawim
National Center For Genetic Engineering And Biotechnology (biotec) Tha
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Rukachaisirikul Vatcharin
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University
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Rukachaisirikul Vatcharin
Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University
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Sukpondma Yaowapa
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University
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Sukpondma Yaowapa
Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University
関連論文
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