COX-1, COX-2 Inhibitors and Antifungal Agents from Croton hutchinsonianus

概要

論文の詳細を見る
Two new compounds, 3'-(4"-hydroxy-3", 5"-dimethoxyphenyl)-propyl benzoate (1) and 3'-(4"-hydroxyphenyl)-propyl benzoate (3) together with known compounds, 3'-(4"-hydroxy-3"-methoxyphenyl)-propyl benzoate (2), poilaneic acid (4), farnesyl acetone (5) and 4-hydroxybenzaldehyde (6) were isolated and identified from the branches of Croton hutchinsonianus. Their structures were determined by spectroscopic methods. The three phenylpropyl benzoates (1-3) were found to exhibit antifungal activity against Candida albicans (IC_<50> 5.36-11.41 μg/ml). Compounds 1-2 (IC_<50> 2.11-4.95 μg/ml) exhibited potent but non-selective activity against the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) whereas 3 (IC_<50> 1.88 μg/ml) preferentially inhibited the enzyme COX-2.
公益社団法人日本薬学会の論文
2006-02-01