Changes in Synaptic Properties in Cortical-Limbic Communications Induced by Repeated Treatments With Fluvoxamine in Rats

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概要

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• There is evidence indicating that dysregulation of coordinated interactions of the cortical-limbic circuitry is associated with anxiety and mood disorders. Our previous study has reported that an enhancement of long-term plasticity in the “limbic-cortical” pathway produced by repeated treatments with fluvoxamine may be involved in the clinical effects of a selective serotonin (5-HT) reuptake inhibitor (SSRI). Here we assessed the effects of single and repeated treatments with fluvoxamine on the synaptic transmission and plasticity in the “cortical-limbic” pathway in vivo. The evoked potentials in the basolateral amygdaloid complex (BLA) by stimulation of the medial prefrontal cortex (mPFC) in halothane-anesthetized rats were recorded. Single administration of fluvoxamine (10 and 30 mg/kg, i.p.) enhanced the efficacy of synaptic transmission at the mPFC-BLA synapses dose-dependently. The enhanced synaptic efficacy induced by 30 mg/kg fluvoxamine was suppressed after long-term administration of fluvoxamine (30 mg/kg per day × 21 days, orally). Repeated treatments with fluvoxamine affected short-term, but not long-term, synaptic plasticity in the mPFC-BLA pathway. These findings indicate that the 5-HTergic system contributes to modulation of synaptic changes in this pathway. Our results also suggest that different changes in synaptic properties in cortical-limbic communications induced by repeated treatments with fluvoxamine may be associated with therapeutic effects of SSRI.

• 社団法人 日本薬理学会の論文
• 2003-06-01

著者

• Matsumoto Misako

  北海道大学 医学研究科免疫学

• Matsumoto M

  Department Of Microbiology And Immunology Hokkaido University Graduate School Of Medicine

• Minami Masaru

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Ohashi Satoshi

  Department of Cardiology, Juntendo University, School of Medicine, Tokyo, and Juntendo Urayasu Hospi

• Togashi Hiroko

  Department of Pharmacology, Hokkaido University Graduate School of Medicine

• MORI Kiyoshi

  Department of Thoracic Diseases, Tochigi Cancer Center

• Yoshioka Mitsuhiro

  Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan

• Yoshioka Mitsuhiro

  Facul.of Pharm.sci. Higashi-nippon-gakuen Univ. 1st Dept.of Pharmacol

• Yoshioka Mitsuhiro

  Hokkaido University Graduate School of Medicine

• Ueno Ken-ichi

  Hokkaido University Graduate School of Medicine

• Ueno Ken-ichi

  Department of Pharmacology, Hokkaido University School of Medicine

• Ohashi Satoshi

  Department Of Cardiology Juntendo University School Of Medicine Tokyo And Juntendo Urayasu Hospital

• Ohashi Satoshi

  Department Of Pharmacology Hokkaido University Graduate School Of Medicine

• Togashi Hiroko

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Ueno Ken-ichi

  Department Of Dermatology Institute Of Clinical Medicine University Of Tsukuba

• MATSUMOTO Machiko

  Department of Pharmacology, Hokkaido University Graduate School of Medicine

• Minami Masaru

  Department Of Cardiovascular Medicine Hokkaldo University School Of Medicine

• Minami Masaru

  Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Health Sciences Univ. Of Hokkaido

• Makita Masaaki

  Dept. Of Cardiovascular Med Hokkaido Univ.

• Mori Kiyoshi

  Department Of Internal Medicine Juntendo University School Of Medicine

• Mori Kiyoshi

  Department Of Pharmacology Hokkaido University Graduate School Of Medicine

• Yoshioka Mitsuhiro

  Department Of Neuropharmacology Hokkaido University Graduate School Of Medicine

• Minami Masaru

  Dept. Of Pharm. School Of Med. Hokkaido Univ.

• MORI Kiyoshi

  Department of Critical Care Medicine, Iwate Medical University

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