Effects of Acute Repetitive Transcranial Magnetic Stimulation on Extracellular Serotonin Concentration in the Rat Prefrontal Cortex

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概要

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• Repetitive transcranial magnetic stimulation (rTMS) changes the function of the cortex. This study clarified the effects of acute rTMS treatment on extracellular serotonin (5-HT) concentrations in the rat prefrontal cortex (PFC) by using in vivo microdialysis methods. Each rat received acute rTMS treatment of the frontal brain at 500 stimuli from twenty trains applied at 25 Hz for 1 s at 1-min intervals between trains. Sham-treated rats received the same handling procedure and sound of the stimulator. Sham treatment increased the extracellular 5-HT levels compared with the non-treated group. However, rTMS treatment using the stimulation intensity of 110% motor threshold eliminated the increase in 5-HT levels induced by the sham treatment. Acute rTMS treatment of the frontal brain is related to the serotonergic neuronal system in the rat PFC, and it may have therapeutic implications for emotional disorders.

• 社団法人 日本薬理学会の論文
• 2003-12-01

著者

• Matsumoto M

  Department Of Microbiology And Immunology Hokkaido University Graduate School Of Medicine

• Minami Masaru

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Togashi Hiroko

  Department of Pharmacology, Hokkaido University Graduate School of Medicine

• Yoshioka Mitsuhiro

  Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan

• Yoshioka Mitsuhiro

  Facul.of Pharm.sci. Higashi-nippon-gakuen Univ. 1st Dept.of Pharmacol

• MANO Yukio

  Departments of Rehabilitation & Physical Medicine, Hokkaido University

• Yoshioka Mitsuhiro

  Hokkaido University Graduate School of Medicine

• Togashi Hiroko

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• MATSUMOTO Machiko

  Department of Pharmacology, Hokkaido University Graduate School of Medicine

• Mano Yukio

  Department Of Rehabilitation Medicine Hokkaido University Graduate School Of Medicine

• Minami Masaru

  Department Of Cardiovascular Medicine Hokkaldo University School Of Medicine

• Minami Masaru

  Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Health Sciences Univ. Of Hokkaido

• KANNO Manabu

  Department of Rehabilitation Medicine, Hokkaido University Graduate School of Medicine

• Makita Masaaki

  Dept. Of Cardiovascular Med Hokkaido Univ.

• Yoshioka Mitsuhiro

  Department Of Neuropharmacology Hokkaido University Graduate School Of Medicine

• Minami Masaru

  Dept. Of Pharm. School Of Med. Hokkaido Univ.

• Kanno Manabu

  Department Of Chemistry Graduate School Of Science Tohoku University

• Kanno Manabu

  Department Of Rehabilitation Medicine Hokkaido University Graduate School Of Medicine

• Mano Yukio

  Department Of Rehabilitation And Physical Medicine Hokkaido University

• Mano Yukio

  Department of Obstetrics and Gynecology, Nagoya University

• Mano Yukio

  Department of Neurology, Nara Medical University

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