Cardiovascular Protective Effects of n-3 Polyunsaturated Fatty Acids With Special Emphasis on Docosahexaenoic Acid
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概要
- 論文の詳細を見る
It is widely accepted that n-3 polyunsaturated fatty acids (PUFAs) rich in fish oils protect against several types of cardiovascular diseases such as myocardial infarction, arrhythmia, atherosclerosis, or hypertension. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may be the active biological components of these effects. Although the precise cellular and molecular mechanisms underlying the beneficial effects are still uncertain, the protective effects of n-3 PUFAs are attributable to their direct effects on vascular smooth muscle cell (VSMC) functions. These n-3 PUFAs activate K+ATP channels and inhibit certain types of Ca2+ channels, probably via at least 2 distinct mechanisms. N-3 PUFAs favorably alter the eicosanoid profile and regulate cytokine-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 via mechanisms involving modulation of signaling transduction events. N-3 PUFAs also modulate VSMC proliferation, migration, and apoptosis. These recent data suggest that modulation of these VSMC functions contribute to the beneficial effects of n-3 PUFAs on various cardiovascular disorders. Furthermore, recent studies strongly suggest that DHA has more potent and beneficial effects than EPA. However, many questions about the cellular and molecular mechanisms still remain to be answered.
- 社団法人 日本薬理学会の論文
- 2003-08-01
著者
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HAMAUE Naoya
Department of Molecular Biosciences, School of Pharmaceutical Sciences, Health Sciences University o
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Minami Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Hamaue N
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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MACHIDA Takuji
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkai
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HIRAFUJI Masahiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkai
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Minami Masaru
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Minami Masaru
Department Of Cardiovascular Medicine Hokkaldo University School Of Medicine
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Minami M
Department Of Hygiene And Public Health Nippon Medical School
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Minami Masaru
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Health Sciences Univ. Of Hokkaido
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Machida Takuji
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Makita Masaaki
Dept. Of Cardiovascular Med Hokkaido Univ.
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Hamaue Naoya
Department Of Molecular Biosciences School Of Pharmaceutical Sciences Health Sciences University Of
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Hirafuji Masahiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Hirafuji Masahiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokhaido
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Minami Masaru
Dept. Of Pharm. School Of Med. Hokkaido Univ.
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Minami Masaru
Department Of Cardiovascular Medicine 1st Department Of Internal Medicine Hokkaido University School
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Hirafuji Masahiko
Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Machida Takuji
Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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