Docosahexaenoic Acid Enhances Cyclooxygenase-2 Induction by Facilitating p44/42, but Not p38, Mitogen-Activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells
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概要
- 論文の詳細を見る
The effect of docosahexaenoic acid (DHA) on cyclooxygenase expression induced by interleukin (IL)-1β and phorbol 12-myristate 13-acetate (PMA) in rat vascular smooth muscle cells (VSMCs) was investigated in order to clarify the cellular mechanism of cardiovascular protective effects. DHA and eicosapentaenoic acid slightly enhanced IL-1β-induced cyclooxygenase (COX)-2, but not COX-1, expression, whereas arachidonic acid had no effect. DHA also slightly enhanced PMA-induced COX-2 expression. DHA stimulated both rapid and prolonged activation of p44/42, but not p38, mitogen-activated protein kinase (MAPK) induced by IL-1β and PMA. These results suggest that DHA enhances the COX-2 expression by selectively facilitating p44/42 MAPK activation in VSMCs.
- 社団法人 日本薬理学会の論文
- 2005-09-20
著者
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HAMAUE Naoya
Department of Molecular Biosciences, School of Pharmaceutical Sciences, Health Sciences University o
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Minami Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Hamaue N
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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MACHIDA Takuji
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkai
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HIRAMATSU Miho
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkai
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HIRAFUJI Masahiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkai
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Minami Masaru
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Minami Masaru
Department Of Cardiovascular Medicine Hokkaldo University School Of Medicine
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Minami M
Department Of Hygiene And Public Health Nippon Medical School
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Minami Masaru
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Health Sciences Univ. Of Hokkaido
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Hiramatsu Miho
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Machida Takuji
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Makita Masaaki
Dept. Of Cardiovascular Med Hokkaido Univ.
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Hamaue Naoya
Department Of Molecular Biosciences School Of Pharmaceutical Sciences Health Sciences University Of
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Hirafuji Masahiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Hirafuji Masahiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokhaido
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Minami Masaru
Dept. Of Pharm. School Of Med. Hokkaido Univ.
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Minami Masaru
Department Of Cardiovascular Medicine 1st Department Of Internal Medicine Hokkaido University School
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Hirafuji Masahiko
Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Machida Takuji
Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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