Myocardial beta-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy
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概要
- 論文の詳細を見る
We evaluated whether myocardial b-adrenergic receptor (b-AR) density, as determined by 11C-CGP12177 PET, could predict improvement of cardiac function by b-blocker carvedilol treatment in patients with idiopathic dilated cardiomyopathy (IDC). Methods: Ten patients with IDC (left ventricular ejection fraction [LVEF] , 45%) were studied. Myocardial b-AR density was estimated using 11C-CGP12177 PET before treatment with carvedilol. Changes of LVEF in response to dobutamine infusion (DLVEF-dobutamine) were also measured by echocardiography. Changes of LVEF (DLVEF-carvedilol) were evaluated after 20 mo of carvedilol treatment. Results: Baseline myocardial b-AR density significantly correlated with DLVEF-carvedilol (r 5 20.88, P , 0.001). In contrast, DLVEF-dobutamine did not correlate with DLVEF-carvedilol (P50.65).Myocardial b-ARdensitywas the significant multivariate independent predictor of DLVEF-carvedilol (b 5 20.88, P , 0.001) among univariate predictors, including functional class (r 5 0.76, P , 0.05), plasma norepinephrine (r 5 0.85, P,0.01), LVEF (r520.64, P,0.05), and age as confounding factors. Furthermore, myocardial b-AR density was significantly correlated with plasma norepinephrine (r 5 20.79, P , 0.01) and LVEF (r 5 0.70, P , 0.05). Conclusion: Myocardial b-AR density is more tightly related to improvement of LVEFcarvedilol than is cardiac contractile reserve in patients with IDC. Patients with decreased myocardial b-AR have higher resting adrenergic drive, as reflected by plasma norepinephrine, and may receive greater benefit from being treated by antiadrenergic drugs.
- Society of Nuclear Medicineの論文
著者
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Tsukamoto Takahiro
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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YAMADA Satoshi
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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KOMATSU Hiroshi
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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Morita Koichi
台湾
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Morita Koichi
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Tamaki Nagara
台湾
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Togashi Hiroko
北海道大学 医学研究科 薬理
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Togashi Hiroko
北海道大学
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Togashi Hiroko
Department Of Pharmacology Hokkaido University School Of Medicine
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Nakata Tomoaki
Second Department Of Internal Medicine Sapporo Medicine University
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Yamada Satoshi
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Togashi Hiroko
Department Of Pharmacology Hokkaido University Graduate School Of Medicine
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Naya Masanao
Department Of Cardiovascular Medicine Hokkaido University
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Komatsu Hiroshi
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Katoh C
Department Of Health Science Hokkaido University Graduate School Of Medicine
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Togashi Hiroko
Safety Research Institute For Chemical Compounds
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Tsukamoto Takahiro
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Togashi Hiroko
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Kuge Yuji
Department Of Tracer Kinetics Hokkaido University School Of Medicine
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Kuge Y
Hokkaido Univ. Sapporo Jpn
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Katoh Chietsugu
Department Of Nuclear Medicine Hokkaido University School Of Medicine
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Tamaki Nagara
Hokkaido University Nuclear Medicine
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Nishijima Kenichi
Department Of Molecular Imaging Hokkaido University Graduate School Of Medicine
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Kuge Yuji
Central Institute Of Isotope Science Hokkaido University
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Tamaki Nagara
Department Of Nuclear Medicine Hokkaido University School Of Medicine
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Togashi Hiroko
Department Of Neuropharmacology Hokkaido University Graduate School Of Medicine
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Tamaki Nagara
Hokkaido University Graduate School Of Medicine Department Of Nuclear Medicine
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Komatsu Hiroshi
Departments Of Cardiovascular Medicine Hokkaido University
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