Incremental Diagnostic Value of Regional Myocardial Blood Flow Quantification Over Relative Perfusion Imaging With Generator-Produced Rubidium-82 PET
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概要
- 論文の詳細を見る
Background: Myocardial blood flow (MBF) can be measured with positron emission tomography (PET) and its quantification should provide diagnostic information beyond that obtained through standard visual analysis. However, this possibility has not been fully studied with PET and generator-produced rubidium-82 (82Rb). We evaluated regional MBF in segments with and without ischemia using 82Rb PET in patients with coronary artery disease (CAD). Methods and Results: Rest and stress 82Rb PET and coronary angiography were performed for 12 patients with CAD. Based on angiography and relative 82Rb perfusion images, segments were classified into 4 groups (Group A: myocardial ischemia with >70% diameter stenosis; Group B: no ischemia with stenosis; Group C: no ischemia without stenosis; Group D: ischemia without stenosis). Rest MBF was similar among the 4 groups. Groups A and B showed reduced hyperemic MBF compared with Group C (P<0.05 vs. Group C) [Group A (n=16) 1.28±0.58ml·min-1·g-1; Group B (n=11) 1.72±0.64ml·min-1·g-1; Group C (n=9) 2.60±1.09ml·min-1·g-1; Group D (n=2) 2.33ml·min-1·g-1]. Coronary flow reserves were inversely correlated with percent diameter stenosis (r=0.76, P<0.0001). Conclusions: Segments with ischemia and coronary stenosis had reduced hyperemic MBF. Segments with coronary stenosis without ischemia also had reduced hyperemic MBF compared with non-stenotic segments. MBF quantification using 82Rb PET may provide additional diagnostic information. (Circ J 2011; 75: 2628-2634)
- 社団法人 日本循環器学会の論文
- 2011-10-25
著者
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YAMADA Satoshi
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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Yoshida K
Furukawa City Hospital
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Yoshinaga Kaoru
The Second Department Of Internal Medicine Tohoku University School Of Medicine
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Tamaki Nagara
台湾
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Nakata Tomoaki
札幌医科大学 医学部
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Togashi Hiroko
北海道大学
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Tsutsui Hiroyuki
Department Of Cardiovascular Medicine
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Tsutsui Hiroyuki
Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Nakata Tomoaki
Second Department Of Internal Medicine Sapporo Medicine University
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Yamada Satoshi
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Tamaki Nagara
Nuclear Medicine Hokkaido University School Of Medicine
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Naya Masanao
Department Of Cardiovascular Medicine Hokkaido University
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Manabe Osamu
Department of Nuclear Medicine, Hokkaido University graduate School of Medicine
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Katoh C
Department Of Health Science Hokkaido University Graduate School Of Medicine
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Yoshinaga Keiichirou
Department Of Nuclear Medicine Hokkaido University
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Yoshinaga Keiichiro
Department Of Cardiology Kagoshima City Medical Association Hospital
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Tsutsui Hiroyuki
Department Of Cardiovasucular Medicine Graduate School Of Medical Sciences Kyushu University
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Dekemp Rob
Cardiac Pet Centre University Of Ottawa Heart Institute
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Togashi Hiroko
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Manabe Osamu
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Klein Ran
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Tamaki Nagara
Hokkaido University Nuclear Medicine
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Yoshinaga Keiichiro
Department Of Nuclear Medicine Hokkaido University
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Tamaki Nagara
Department Of Nuclear Medicine Hokkaido University School Of Medicine
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Nakata Tomoaki
Department Of Cardiology Sapporo Medical University School Of Medicine
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Tsutsui Hiroyuki
Department Of Cardiovasucular Medicine Hokkaido University Graduate School Of Medicine
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Yoshinaga Keiichiro
Department Of Photobiology Division Of Molecular Cellular Imaging Hokkaido University Graduate Schoo
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Tamaki Nagara
Hokkaido University Graduate School Of Medicine Department Of Nuclear Medicine
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Sakakibara Mamoru
Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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KATOH Chietsugu
Health Sciences, Hokkaido University Graduate School of Medicine
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MANABE Osamu
Nuclear Medicine, Hokkaido University Graduate School of Medicine
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KLEIN Ran
Nuclear Medicine, Hokkaido University Graduate School of Medicine
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NAYA Masanao
Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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YAMADA Shiro
Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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DEKEMP Robert
National Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute
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Klein Ran
Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Naya Masanao
Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Katoh Chietsugu
Health Sciences Hokkaido University Graduate School Of Medicine
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Tsutsui Hiroyuki
Departments Of Cardiovascular Medicine Graduate School Of Medical Sciences Kyushu University:japanese Coronary Intervention Study (jcis) Group
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