Influence of Contrast Ultrasonography With Perflutren Lipid Microspheres on Microvessel Injury
スポンサーリンク
概要
- 論文の詳細を見る
Microbubbles have been reported to enhance ultrasound (US)-related side effects in animal systems. The present study investigated the influence of contrast ultrasonography (US) with perflutren lipid microspheres, a recently developed second-generation contrast agent, on microvessels. Rat mesentery was exposed to 1.8-MHz pulsed US with intravenous injection of perflutren (0.1 or 1.0 ml/kg) or Levovist^<【〇!R】> (300mg/kg), and the microvessel bleeding and endothelial cell injury was examined. Impaired endothelial cells were identified by the fluorescence of propidium iodide. Microvessel bleeding was examined also in the rat myocardium. The interaction between 0.1 ml/kg of perflutren and US exposure did not cause microvessel bleeding, and did not increase endothelial cell injury compared with the sham operation, unless frequent, strong US exposure occurred. When the dose was increased to 1.0 ml/kg, the combination of perflutren and US exposure resulted in capillary bleeding and increased endothelial cell injury in capillaries and venules (p<0.01). However, the incidence of microvessel bleeding and endothelial cell injury did not exceed that with Levovist^<【〇!R】> microbubbles. In the myocardium, microvessel bleeding was not observed under any conditions. In conclusion, perflutren lipid microspheres enhanced US-related microvessel injury as with other contrast agents at the dose of 1.0 ml/kg, but not with 0.1 ml/kg and the appropriate US setting. (Circ J 2003 ; 67 : 630-636)
- 社団法人日本循環器学会の論文
- 2003-06-20
著者
-
YAMADA Satoshi
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
-
Miyatake Kunio
Cardiovascular Division Osaka Minami Medical Center
-
Saito Muneyasu
Department Of Cardiology Tokyo Women's Medical University
-
KOBAYASHI NOBUHIKO
Department of Dermatology, Nara Medical University
-
KUDO Nobuki
Laboratory of Biomedical Instrumentation and Measurements, Graduate School of Information Science an
-
Yamada Satoshi
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
-
Saito Muneyasu
First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University
-
Yasu Takanori
Department Of Clinical Pharmacology & Therapeutics
-
Yasu Takanori
Department Of Clinical Pharmacology & Therapeutics University Of The Ryukyus Graduate School Of
-
KAWAKAMI Masanobu
Department of Medicine, Jichi Medical School
-
Miyatake Kunio
Cardiology Division National Cardiovascular Center
-
Kuroki Masatoshi
Department of Integrated Medicine I, Omiya Medical Center, Jichi Medical School
-
Kuroki Masatoshi
Towa Hospital
-
Kawakami Masanobu
Department Of Comprehensive Medicine Jichi Medical University Omiya Medical Center
-
Saito Muneyasu
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical University
-
Kobayashi Nobuhiko
Department Of Medicine Jichi Medical School Omiya Medical Center
-
Kobayashi Nobuhiko
Depart. Dermatol. Nara Medical Univ.
-
Kubo Norifumi
Cardiovascular Division Jichi Medical University Saitama Medical Center
-
Kudo Nobuki
Laboratory Of Biochemical Instrumentation & Measurements Research Associate Graduate School Of E
-
Saito Muneyasu
Cardiovascular Division Department Of Integrated Medicine I
-
Tada Yuuko
Division Of Cardiology Saitama Medical Center Jichi Medical School
-
Kuroki Masatoshi
Department Of General Medicine Omiya Medical Center Jichi Medical School
-
Kanda M
Department Of Surgical Neurology Jichi Medical School Omiya Medical Center
-
Yasu Takanori
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshima University
-
KUROKI Masatoshi
Department of Cardiology, Jichi Medical School
関連論文
- Discharge use of angiotensin receptor blockers provides comparable effects with angiotensin-converting enzyme inhibitors on outcomes in patients hospitalized for heart failure
- Angiotensin II Receptor Blocker, Valsartan, Increases Myocardial Blood Volume and Regresses Hypertrophy in Hypertensive Patients
- PE-482 Does Assessment of Atrial Contractile Properties Predict Paroxysmal Atrial Fibrillation? : A Color Doppler Strain Rate Imaging Study(PE081,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 4 (A),Poster Session (English),The 73rd Annual Scientific M
- OE-128 Left Ventricular Global Strain and Dyssynchrony Demonstrated by Speckle Tracking Echocardiography : A Comparison of Apical and Septal Right Ventricular Pacing(OE22,Echo/Doppler (Myocardium) (I),Oral Presentation (English),The 73rd Annual Scientific
- PJ-218 Bachmann's Bundle Pacing Gets an Advantage over Right Atrial Appendage Pacing on Atrial Contraction Synchrony : A Strain Rate Imaging Study(Arrhythmia, therapy(24)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circu
- OJ-247 Influence of Preload Changes Mediated by Upper Body Tilting Position on Left Ventricular Diastolic Indices in chronic heart failure subjects(Echo / Doppler(04)(I),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circu
- In-hospital and One-year Outcome of Patients with Acute Myocardial Infarction after Reperfusion Therapy
- PE-482 Does Assessment of Atrial Contractile Properties Predict Paroxysmal Atrial Fibrillation? : A Color Doppler Strain Rate Imaging Study(PE081,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 4 (A),Poster Session (English),The 73rd Annual Scientific M
- OE-128 Left Ventricular Global Strain and Dyssynchrony Demonstrated by Speckle Tracking Echocardiography : A Comparison of Apical and Septal Right Ventricular Pacing(OE22,Echo/Doppler (Myocardium) (I),Oral Presentation (English),The 73rd Annual Scientific
- Comparison of the Effects of Telmisartan and Olmesartan on Home Blood Pressure, Glucose, and Lipid Profiles in Patients with Hypertension, Chronic Heart Failure, and Metabolic Syndrome
- PJ-218 Bachmann's Bundle Pacing Gets an Advantage over Right Atrial Appendage Pacing on Atrial Contraction Synchrony : A Strain Rate Imaging Study(Arrhythmia, therapy(24)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circu
- OJ-247 Influence of Preload Changes Mediated by Upper Body Tilting Position on Left Ventricular Diastolic Indices in chronic heart failure subjects(Echo / Doppler(04)(I),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circu
- PE-017 Metabolic Syndrome Contributs to Aspirin-resistant Thromboxane Biosynthesis via Inducing Platelets COX-2 Expression in Patients with Stable Angina(Angina pectoris, basic/clinical-3 (IHD) PE3,Poster Session (English),The 70th Anniversary Annual Scie
- Discharge use of angiotensin receptor blockers provides comparable effects with angiotensin-converting enzyme inhibitors on outcomes in patients hospitalized for heart failure
- The Functional Profiles of Circulating T Lymphocytes Distinguish Patients with Stable and Unstable Angina
- Use of Beta-blockers at Discharge in Patients With Acute Myocardial Infarction Data From the HIJC AMI data-base
- Restrictive Cardiomyopathy With Right-Sided Dominant Heart Failure After Sinus Conversion From Atrial Fibrillation : Case Report
- Papillary Muscle Suspension Concomitant With Approximation for Functional Mitral Regurgitation
- Renal Functions in Hypertensive Subjects Evaluated by Computer-aided Radioisotope Renogram : Prognosis and Treatment of Renal Hypertension
- Quantitative Measurement of Echo Contrast Concentration by Pulse Subtraction Imaging : A Study Using New Contrast Agents Definity and Imagent(Echo/Doppler 7 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- A fundamental study for quantitative measurement of ultrasound contrast concentration by low mechanical index contrast ultrasonography
- Analysis of Ventricular Wall Motion Using Color-Coded Tissue Doppler Imaging System
- New Abutment Build-up Method Using FRP Combined with Metal Casting
- Right ventricular diastolic dysfunction in patients with left ventricular hypertrophy : analysis of right ventricular myocardial relaxation using two-dimensional speckle tracking imaging
- PJ-169 Abnormal Apical Rotation in Patients with Left Ventricular Hypertrophy Determined by Two-Dimensional Ultrasound Speckle Tracking Imaging(Echo/Doppler-13 (I) PJ29,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japane
- PE-584 Plasma NT-proBNP Concentration is a Sensitive Marker of Diastolic Dysfunction and Arterial Remodeling in Hypertension(Hypertension, clinical-7 (H) PE102,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circula
- Usefulness of Left Parasternal Approach for the Continuous-Wave Doppler Measurement of Left Ventricular Outflow Tract Pressure Gradient in Patients With Hypertrophic Cardiomyopathy
- PJ-283 Early Detection of High Risk Patients for Atherosclerosis in Untreated Hypertensive Patients(Atherosclerosis, Clinical 3 (IHD) : PJ48)(Poster Session (Japanese))
- PJ-135 Feasibility of the Assessment of Left Ventricular Diastolic Function Using Doppler-Derived Early Diastolic Peak Strain Rate(Echo/Doppler 6 (I) : PJ23)(Poster Session (Japanese))
- PJ-020 Evaluation of Circumferential and Longitudinal Myocardial Contraction Using Tissue Doppler Strain Measurement in Patients with Generalized Left Ventricular Myocardial Impairment(Echo/Doppler 2 (I) : PJ4)(Poster Session (Japanese))
- Measuring Medium-Sized Muscular Arteries Using a Novel Broadband 15-MHz Linear Array Probe
- Usefulness of Color Tissue Doppler Imaging in the Assessment of Left Ventricular Diastolic Function : Comparison with Color M-Mode Doppler Technique
- Abnormal Diastolic Flow Velocity Pattern in the Distal Left Anterior Descending Coronary Artery in Patients with Apical Hypertrophy
- Short and long term prognosis of non-ST-segment elevation MI(NSTEMI) : Multicenter study of HIJC group
- Prognostic risk stratification of in-hospital complications associated with acute myocardial infarction : HIJC group prospective cohort multicenter study
- Comparison of long-term clinical outcome of coronary stenting versus balloon angioplasty in acute myocardial infarction-Multicenter study of HIJC group
- Myocardial Blood Volume Assessed by Contrast Echocardiography is Associated with Contractile Reserve in Patients with Idiopathic Dilated Cardiomyopathy(Echo/Doppler 7 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-026 Primary Results of the Assessment of Coronary Heart Disease with Myocardial Contrast Echcardiography (ACTMCE1) Trial(Recent Advance in Echocardiography-1 (I) FRS6,Featured Research Session,The 70th Anniversary Annual Scientific Meeting of the Japa
- Management and Evaluation of Non-supervised Home Exercise Program in a Convalescent Phase of Acute Myocardial Infarction : 53rd Annual Scienific Seeesion of the Japanese Circulation Society
- CHANGES IN EXERCISE TOLERANCE AFTER PERCUTANEOUS TRANSVENOUS MITRAL COMMISSUROTOMY(PTMC) : Exercise Test, Rehabilitation : 53 Annual Scientific Meeting, Japanese Circulation Society
- RELATIONSHIP OF HEART RATE, BLOOD PRESSURE, AND OXYGEN CONSUMPTION RESPONSES TO ORDINARY ACTIVITIES : Exercise Test (I) : FREE COMMUNICATIONS (V) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Data Mining of the Best Treatments of Chronic Heart Failure and Proposal of Adenosine Therapy as a New Treatment
- Advanced Glycation End Products Upregulate Endothelial COX-2 Expression and Induce Aspirin Resistant Thromboxane Synthesis by Platelets(Infection/Inflammation/Immunity 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Simple and Accurate Method to Identify Early Ventricular Contraction Sites in Wolff-Parkinson-White Syndrome by High Frame-Rate Tissue Velocity Imaging
- Functional recovery with dobutamine stress echocardiography is dependent on maintenance of oxidative metabolic response : Comparison with carbon-11 acetate PET
- Quantitative Assessment of Wall Motion Using Myocardial Strain
- Influence of Left Ventricular Diastolic Function on the Clinical Course of Patients with Hypertrophic Cardiomyopathy
- PJ-290 Increased Coronary Vascular Resistance during Hyperemia was Associated with Reduced Myocardial Blood Volume in Patients with Hypertrophic Cardiomyopathy(Echo/Doppler(13)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese
- PJ-289 Angiotensin II Receptor Blockade Could Regress Left Ventricular Hypertrophy and Improve Myocardial Blood Volume in Hypertensive Patients(Echo/Doppler(13)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
- PJ-438 Predictive Value of Myocardial Blood Volume Assessed by Contrast Echocardiography for Functional Improvement in Patients with Idiopathic Dilated Cardiomyopathy(Cardiomyopathy, basic/clinical-6, The 71st Annual Scientific Meeting of the Japanese Cir
- PJ-251 Clinical Significance of Dense Spontaneous Echo Contrast Detected in the Carotid Arteries of Patients with Ischemic Cerebrovascular Disease(Echo/Doppler-16, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-169 Reduced Myocardial Blood Volume is Associated with Left Ventricular Hypertrophy in Hypertensive Patients(Echo / Doppler-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-169 Reduced Myocardial Blood Volume is Associated with Impairment of Regional Myocardial Flow Reserve in Hypertrophic Cardiomyopathy(Echo/Doppler-4 (I) OJ29,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Cir
- OJ-392 A New Method to Measure Myocardial Strain along the Left Ventricular Circumference Using Tissue Doppler Echocardiography(Echo/Doppler 14 (I) : OJ48)(Oral Presentation (Japanese))
- 6 Clinical Significance of Myocardial Blood Volume Measured by Contrast Echocardiography in Patients with Cardiac Hypertrophy and Failure(Frontiers in Diagnostic Echocardiography,Symposium 14 (SY-14) (M),The 73rd Annual Scientific Meeting of The Japanese
- Comparison of Automatic Boundary Detection and Manual Tracing Technique in Echocardiographic Determination of Left Atrial Volume
- Vasospastic Total Occlusion at the Left Main Tract in a Single Coronary Artery
- -380- EFFICACY OF NON-SUPERVISED HOME EXERCISE PROGRAM IN CONVALESCENT PHASE OF ACUTE MYOCARDIAL INFARCTION : EVALUATION OF THE EFFECTS BY ANAEROBIC THRESHOLD
- -274- MECHANISMS OF IMPENDING MYOCARDIAL INFARCTION : RELATION WITH ST-SEGMENT SHIFTS DURING ISCHEMIC ATTACKS, INTRA-CORONARY THROMBUS AND FIXED STENOSIS OF THE CORONARY ARTERIES : Ischemic Heart Diseases : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 51t
- FRS-096 C-reactive protein upregulatesTLR-4 expression through NF-κB activation in vascular endothelial cells(Inflammation and Cardiovascular Disease (IHD) : FRS12)(Featured Research Session (English))
- In Vivo Echocardiographic Detection of Cardiovascular Lesions in Apolipoprotein E-Knockout Mice Using a Novel High-Frequency High-Speed Echocardiography Technique
- A wide spectrum of cellagen vascular and autoimmune diseases in transgenic rats carrying the env-pX gene of human T lymphocyte virus type I
- Clinical Analysis of Myocardial Perfusion and Metabolism in Patients With Hypertrophic Cardiomyopathy by Single Photon Emission Tomography and Positron Emission Tomography
- AN EXPERIMENTAL STUDY ON THE REGULATORY MECHANISM OF VASCULAR SMOOTH MUSCULAR TONE BY NON-ADRENERGIC, NON-CHOLINERGIC MEDIATORS
- -0972-AUGMENTATION OF MITRAL REGURGITATION DURING EXERCISE IN PATIENTS WITH MITRAL STENOSIS : RELATION TO PLIABILITY OF THE LEAFLET : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PE-307 Left Ventricular Noncompaction Associated With Mutations in Cardiac Na Channel Gene SCN5A(Cardiomyopathy, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 3 Does Cardiac Volume Reduction Surgery with Overlapping Left Ventriculoplasty have Adverse Effect on Left Ventricular Diastolic Function?(Left Ventriculoplasty, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Quantitative Assessment of Regional Contraction Using Newly Developed Angle-Corrected Color Strain Imaging System
- Carvedilol Treatment Prevents the Attenuation of Left Ventricular Contractile Response to Dobutamine in Patients with Dilated Cardiomyopathy
- Comparative Left Ventricular Functional and Neurohumoral Effects of Chronic Treatment With Carvedilol Versus Metoprolol in Patients With Dilated Cardiomyopathy
- IS146 Determination of human mitral inertance using color M-mode Doppler echocardiography.
- IS139 Strain rate imaging : a new method to quantify regional myocardial contractility.
- Presence of Endothelial Dysfunction Is the Major Determinant of Maladaptive Vascular Remodeling in Brachial Arteries of Untreated Hypertensive Patients
- A Novel Method for Estimating a Normalized Value of Myocardial Blood Volume by Compensating for Ultrasound Attenuation in Contrast Echocardiography
- Vascular Remodeling of the Brachial Artery and its Relation to Endothelial Function in Untreated Hypertensive Patients
- Brachial Artery Intima-Medial Thickening and Preserved Fibrinolysis Indicate Adaptive Vascular Remodeling in Japanese Uncomplicated Hypertensives
- Survey on Oral Trauma of The Children in Gifu City Schools(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- Coordination of Laryngeal Movements and Orofacial Muscle Activities in Swallowing
- Changes in the Aortic and Pulmonary Diameters in a Fetus with Hypoplastic Left Heart Syndrome
- Green-Schwarz Superstring Action for (p,q)-Strings from a Wrapped Supermembrane on a 2-Torus(Particles and Fields)
- Wrapped supermembrane on vanishing 2-torus
- Influence of Contrast Ultrasonography With Perflutren Lipid Microspheres on Microvessel Injury
- Myocardial beta-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy
- Assessment of Contractile Reserve of Infarcted Myocardium Using a Novel Index of Intramyocardial Blood Volume in Contrast Echocardiography
- Body Mass Index Is an Independent Predictor of Long-Term Outcomes in Patients Hospitalized With Heart Failure in Japan : A Report Frown the Japanese Cardiac Registry of Hears Failure in Cardiology (JCARE-CARD)
- Influence of irradiation conditions on the deformation of pure titanium frames in laser welding
- Prognostic Significance of Left Ventricular Diastolic Dysfunction Assessed by Color M-mode Doppler Echocardiography in Patients With Chronic Left Ventricular Systolic Dysfunction
- An Enhanced Method for Measuring Cardiac Output Using Doppler Color Flow Echocardiography
- Characterization of Linear Poly(N-isopropylacrylamide) and Cloud Points in its Aqueous Solutions
- Spatial Homogenization of Acoustic Pressure by Low-Power Myocardial Contrast Echocardiography Using FS69 : In Vitro and in Vivo Studies
- Novel Strain Rate Index of Contractility Loss Caused by Mechanical Dyssynchrony : A Predictor of Response to Cardiac Resynchronization Therapy
- Predictors of Long-Term Adverse Outcomes in Elderly Patients Over 80 Years Hospitalized With Heart Failure : A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)
- Normal Values of Real-Time 3-Dimensional Echocardiographic Parameters in a Healthy Japanese Population : The JAMP-3D Study
- Incremental Diagnostic Value of Regional Myocardial Blood Flow Quantification Over Relative Perfusion Imaging With Generator-Produced Rubidium-82 PET
- Early diastolic mitral annular velocity at the interventricular septal annulus correctly reflects left ventricular longitudinal myocardial relaxation
- Decreased glomerular filtration rate is a significant and independent risk for in-hospital mortality in Japanese patients with acute myocardial infarction : report from the Hokkaido acute myocardial infarction registry
- Loop Diuretic Use at Discharge Is Associated With Adverse Outcomes in Hospitalized Patients With Heart Failure : A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)
- Mode of Death in Patients With Heart Failure and Reduced vs. Preserved Ejection Fraction : Report From the Registry of Hospitalized Heart Failure Patients
- Sleep-Disordered Breathing Is an Independent Risk Factor of Aborted Sudden Cardiac Arrest in Patients With Coronary Artery Spasm
- Strain Rate Dispersion Index Can Predict Changes in Left Ventricular Volume and Adverse Cardiac Events Following Cardiac Resynchronization Therapy