IMPAIRMENT OF HEART MITOCHONDRIA INDUCED BY LARGE DOSES OF SYMPATHOMIMETICS AND ADRENERGIC BLOCKING AGENTS IN GUINEA PIGS
スポンサーリンク
概要
- 論文の詳細を見る
By using the polarographic technique with a rotating electrode, respiratory function was tested in heart mitochondria which were obtained from guinea pigs pretreated with sympathomimetics and adrenergic blocking agents. The degree and duration of mitochondrial impairment were dose-dependent. Alpha and beta adrenergic blocking agents both induced the same type of obstruction of mitochondrial respiration as was seen with sympathomimetics. It has been suggested that a hypoxic state of the myocardium induced by sympathomimetics is partially related to the onset of respiratory obstrution in myocardial mitochondria. No relationship was observed between the catecholamine-induced impairment of mitochondria and adrenergic receptors in the myocardium.
- 日本トキシコロジー学会の論文
- 1976-01-15
著者
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Monma Yoshio
Department Of Pharmacology School Of Medicine Hokkaido University:(present Address)department Of Pha
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Saito Hideya
Department Of Cardiovascular Medicine And Pharmacology. Hokkaido University
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Satoh H
Environmental Health Science Tohoku University Graduate School Of Medicine
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Saito Hideya
Department Of Basic Sciences Japanese Red Cross Hokkaido College Of Nursing
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Saito Hideya
Department Of Pharmacology School Of Medicine Hokkaido University
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Tanabe Tsuneyoshi
Department Of Toxicology Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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Tanabe Tsuneyoshi
Department Of Pharmacology School Of Medicine Hokkaido University:(present Address)department Of Pha
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Tanabe Tsuneyoshi
Department Of Pharmacology And Toxitology Faculty Of Pharmaceutical Sciences
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Tanabe Tsuneyoshi
Dept. Of Pharm. School Of Med. Hokkaido Univ.
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Monma Yoshio
Department Of Pharmacology And Toxitology Faculty Of Pharmaceutical Sciences
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Monma Y
National Research Inst. Metals Tsukuba‐city Jpn
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Satoh Hiroshi
Environmental Health Science Tohoku University Graduate School Of Medicine
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MONMA Yoshio
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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