INHIBITORY EFFECT OF NICOTINE ON CHEMILUMINESCENCE RESPONSE OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES STIMULATED BY OPSONIZED ZYMOSAN IN VITRO
スポンサーリンク
概要
- 論文の詳細を見る
Effect of nicotine on chemiluminericence (CL) responses of human polymorphonuclear leukocytes (PMN) in vitro was investigated. Nicotine, ranging from 10^<-5> to 5×10^<-4> M, showed a concentration-dependent inhibition of the CL induced by 2.5 mg of opsonized zymosan. This inhibitory effect of nicotine (10^<-4> M) on CL was not affected by atropine (10^<-4> M), hexamethonium (10^<-5> M) or acetyl β-methylcholine (10^<-4> M). These results indicate that nicotine directly acts to PMN with no relation of cholinergic affecting receptors. As to cytotoxic effects on PMN, assessed by the methods of trypan blue exclusion and of lactate dehydrogenase leakage from the cells, nicotine showed no cytotoxic effect on PMN in its range of 10^<-5> to 5×10^<-4> M. It is concluded that tobacco alkaloid nicotine could directly inhibit phagocytizing function of PMN. Furthermore, it is presumed that PMN circulating in the respiratory organs in tobacco smoking would be exposed to high concentrations of nicotine, and that the nicotine incorporated into the circulating system could suppress PMN functions resulting in harmful influences on the host defense mechanisms.
- 日本トキシコロジー学会の論文
- 1984-02-25
著者
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SUDO Jun-ichi
Department of Pharmacology, Faculty of Medicine, University of Tokyo
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Tanabe Tsuneyoshi
Department Of Toxicology Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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Tanabe Tsuneyoshi
Department Of Pharmacology And Toxitology Faculty Of Pharmaceutical Sciences
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Sudo Jun-ichi
Department Of Toxicology Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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Sudo Jun-ichi
Department Of Clinical Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Health Science
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Kameda Haruko
Department Of Toxicology Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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SASAGAWA SUMIKO
Department of Pharmacology, Hoshi College of Pharmacy
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Sasagawa Sumiko
Department Of Pharmacology Hoshi College Of Pharmacy
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Sasagawa Sumiko
Department Of Toxicology Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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TANABE Tsuneyoshi
Department of Toxicology, Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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KAMEDA Haruko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Higashi-Nippon Gakuen University
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