THE MODIFICATION OF INOTROPIC ACTION OF OUABAIN BY 6-HYDROXYDOPAMINE AND α-METHYL-P-TYROSINE IN DOGS
スポンサーリンク
概要
- 論文の詳細を見る
The action of ouabain on myocardial inotropism pretreated with 6-hydroxydopamine and α-methyl-p-tyrosine was studied. Inotropic action of ouabain was not changed by depletion of catecholamines in the brain, in which the central sympathetic neurons were destroyed by an intraventricular administration of 6-hydroxydopamine. Systemic administration of 6-hydroxydopamine and α-methyl-p-tyrosine reduced ventricular catecholamines to 5.3% and 20.8% of the control, respectively. Percent increase of contractility by ouabain after the pretreatment of 6-hydroxydopamine and α-methyl-p-tyrosine was reduced to 16.7% and 50.2% of the control, respectively. The results obtained suggest that catecholamines in the myocardium play some important role in producing cardiotonic action of cardiac glycosides. Brain catecholamines or the central sympathetic nervous system do not appear to participate in the exertion of the positive inotropic action of cardiac glycosides.
- 社団法人 日本薬理学会の論文
著者
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Saito Hideya
Department Of Basic Sciences Japanese Red Cross Hokkaido College Of Nursing
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Tanabe Tsuneyoshi
Department Of Pharmacology And Toxitology Faculty Of Pharmaceutical Sciences
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SHUDO Isami
Department of Pharmacology, Hokkaido University School of Medicine
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