TIME COURSE OBSERVATION ON METAPROTERENOL DISTRIBUTION IN RATS

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概要

• 論文の詳細を見る

• The plasma <SUP>3</SUP>H-radioactivity level showed a high value 1 hr after intraperitoneal injection of <SUP>3</SUP>H-metaproterenol and it lowered lineraly to reach 40% of the peak level 5 hr after administration. Radioactivity distributed to the kidneys and liver was markedly higher than that in other organs. Forty per cent of the amount given orally was excreted in the 24 hr urine specimen. The major part of metaproterenol was excreted in urine as an unchanged compound in the early stages after administration and the remainder in the form of glucuronide in the late stages. It is concluded that the absorbed metaproterenol remains unmetabolized for a considerable length of time in the body and high plasma levels are maintained for a relatively long period.

• 社団法人 日本薬理学会の論文

著者

• SHUDO Isami

  Department of Pharmacology, Hokkaido University School of Medicine

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• EFFECT OF 6-HYDROXYDOPAMINE ON CARDIOTOXICITY OF OUABAIN IN GUINEA PIGS
• TIME COURSE OBSERVATION ON PROTOKYLOL DISTRIBUTION IN RATS FOLLOWING PROTOKYLOL ADMINISTRATION
• TIME COURSE OBSERVATION ON METAPROTERENOL DISTRIBUTION IN RATS

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