Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats
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概要
- 論文の詳細を見る
Nigella sativa (family Ranunculaceae) is an annual plant that has been traditionally used on the Indian subcontinent and in Middle Eastern countries. In this study, we investigated the effect of N. sativa oil on the drug-metabolizing cytochrome P450 (CYP) enzymes and whether it has a protective effect against the acute hepatotoxicity of CCl4. Intraperitoneal injection of rats with CCl4 drastically decreased CYP2E1, CYP2B, CYP3A2, CYP2C11, and CYP1A2 mRNA and protein expressions. Oral administration of 1 ml/kg N. sativa oil every day for one week prior to CCl4 injection alleviated CCl4-induced suppression of CYP2B, CYP3A2, CYP2C11, and CYP1A2. Moreover, CCl4 increased iNOS and TNFα mRNA, while N. sativa oil administration for one week prior to CCl4 injection downregulated the CCl4-induced iNOS mRNA and upregulated IL-10 mRNA. These results indicate that N. sativa oil administration has a protective effect against the CCl4-mediated suppression of hepatic CYPs and that this protective effect is partly due to the downregulation of NO production and up-regulation of the anti-inflammatory IL-10.
- The Graduate School of Veterinary Medicine, Hokkaido Universityの論文
著者
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Ishizuka Mayumi
北海道大学 獣医学研究科毒性学
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Ishizuka Mayumi
北海道大学 獣医学研究科環境獣医科学講座毒性学
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Ishizuka Mayumi
北海道大学 獣医学研究科
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Muzandu Kaampwe
北海道大学 獣医学研究科
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Muzandu Kaampwe
北海道大学 獣医学研究科環境獣医科学講座毒性学
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坂本 健太郎
北海道大学大学院獣医学研究科毒性学教室
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Ishizuka Mayumi
Hokkaido Univ. Sapporo Jpn
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Fujita S
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Fujita Shoichi
北海道大学 獣医研究 環境獣医
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Saito Masayuki
日本獣医生命科学大学 獣医保健看護学科臨床部門
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Muzandu K
Hokkaido Univ. Sapporo Jpn
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Sakamoto Kentaro
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Sakamoto Kentaro
Laboratory Of Toxicology Department Of Environmental Veterinary Science School Of Veterinary Medicin
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Sakamoto Kentaro
Department Of Environmental Veterinary Sciences Graduate School Of Veterinary Medicine Hokkaido Univ
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Ishizuka Mayumi
Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
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Bohi Khloodm.el.
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Fujita Shoichi
Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
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Ishizuka Mayumi
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Sakamoto Kentaro
Hokkaido Univ. Sapporo
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