Cytochrome P450 1A Dependent Activities in Deer, Cattle, and Horses
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概要
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The objective of this study was to investigate and characterize the metabolic activities of CYP1A in deer, cattle, and horses in a comparison to those of rats using ethoxyresorufin O-deethylation (EROD) and methoxyresorufin O-demethylation (MROD) assays. We performed an inhibition study for these activities using anti-rat CYP1A1 antibody, and identified that these activities were due to CYP1A subfamily. Inter-species difference in the CYP1A dependent activities was highly observed in this study. Especially, we found that the horse had the highest EROD and MROD activities among the examined animal species in this study. In the kinetic analysis, horse showed the highest Vmax and catalytic efficiency (Vmax/Km) followed by cattle, deer and finally rats.
- 社団法人 日本獣医学会の論文
著者
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FUJITA Shoichi
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
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Ishizuka Mayumi
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Sakamoto Kentaro
Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University
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IKENAKA Yoshinori
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
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Ishizuka Mayumi
Laboratory Of Toxicology
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Darwish Wageh
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
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Eldaly Elsaid
Food Control Department, Faculty of Veterinary Medicine, Zagazig University
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OHNO Marumi
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
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Sakamoto Kentaro
Laboratory Of Toxicology Department Of Environmental Veterinary Science School Of Veterinary Medicin
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Fujita Shoichi
Laboratory Of Toxicology
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