Dioxin Sensitivity-Related Two Critical Amino Acids of Arylhydrocarbon Receptor May Not Correlate with the Taxonomy or Phylogeny in Avian Species
スポンサーリンク
概要
- 論文の詳細を見る
There are two arylhydrocarbon receptor (AhR) isoforms in birds, AhR1 and AhR2. The varying sensitivity of AhR is reported to be related to two critical amino acids at positions 325 and 381 in the AhR1 ligand-binding domain. In this study, seven avian species whose in vivo dioxin sensitivity was known, and 13 species with no data regarding their in vivo dioxin sensitivity were examined. The two critical amino acids in the ligand-binding domain were investigated in avian species, and the results were compared with the taxonomy or phylogenetic trees for the bird AhR proteins. We found that the two critical amino acids did not correlate with the taxonomy or phylogeny of these proteins, suggesting that dioxin sensitivity was independent of taxonomy.
著者
-
IKENAKA Yoshinori
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
-
Ishizuka Mayumi
Laboratory Of Toxicology
-
YAMAMOTO Hideaki
Maruyama Zoo
-
NAKAYAMA Shouta
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
-
KAWAI Yusuke
Laboratory of Toxicology, Department of Environmental Veterinary Science, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo, Hokkaido 060–0818, Japan
-
FUJISAWA Nozomi
Laboratory of Toxicology, Department of Environmental Veterinary Science, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo, Hokkaido 060–0818, Japan
-
IKENAKA Yoshinori
Laboratory of Toxicology, Department of Environmental Veterinary Science, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo, Hokkaido 060–0818, Japan
-
IKENAKA Yoshinori
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan
-
NAKAYAMA Shouta
Laboratory of Toxicology, Department of Environmental Veterinary Science, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo, Hokkaido 060–0818, Japan
-
NAKAYAMA Shouta
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan
関連論文
- Diazepam Metabolism in Kidney of Male and Female Rats of Varying Strain
- Expression and Sequence of CYP1A1 in Camel
- Pesticide resistance in wild mammals : Mechanisms of anticoagulant resistance in wild rodents
- Effect of components of green tea extracts, caffeine and catechins on hepatic drug metabolizing enzyme activities and mutagenic transformation of carcinogens
- Lycopene and beta-carotene ameliorate catechol estrogen-mediated DNA damage
- Antigenotoxic effect of Pleurotus cornucopiae extracts on the mutagenesis of Salmonella typhimurium TA 98 elicited by benzo[a]pyrene and oxidative DNA lesions in V 79 hamster lung cells
- Iodine intake as a possible cause of discontinuous decline in sperm counts : A re-evaluation of historical and geographic variation in semen quality
- O12-03 Intracellular dynamics of an endogenous dopaminergic neurotoxin, norsalsolinol, in PC12 cells
- Environmental monitoring by Cytochrome P450:Alterations of monooxygenase activities in Eriocheir japonicus in response to water pollution.
- Morphological Features and Blood Parameters of Weddell Seal (Leptonychotes weddellii) Mothers and Pups during the Breeding Season(Physiology)
- Xenobiotic metabolizing enzymes as biomarkers for levels of environmental pollution
- Cytochrome P450 1A Dependent Activities in Deer, Cattle, and Horses
- Cioning, Tissue Distribution, and Functional Expression of Two Novel Rabbit Cytochrome P450 Isozymes, CYP2D23 and CYP2D24
- Identification and Phylogenetic Analysis of Novel Cytochrome P450 1A Genes from Ungulate Species
- Molecular Cloning of Novel Cytochrome P450 1A Genes from Nine Japanese Amphibian Species
- A Novel Mutation in VKORC1 and Its Effect on Enzymatic Activity in Japanese Warfarin-Resistant Rats
- Accumulation of Metals in the Liver and Kidneys of Cattle from Agricultural Areas in Lusaka, Zambia
- Downregulation of Hepatic Cytochrome P450 3A in Mice Infected with Babesia microti
- Dioxin Sensitivity-Related Two Critical Amino Acids of Arylhydrocarbon Receptor May Not Correlate with the Taxonomy or Phylogeny in Avian Species
- Repeated Treatment with Furazolidone Induces Multiple Cytochrome P450-Related Activities in Chicken Liver, but not in Rat Liver
- Effects of polycyclic aromatic hydrocarbons (PAHs) on an aquatic ecosystem : acute toxicity and community-level toxic impact tests of benzo[a]pyrene using lake zooplankton community