Effects of Brewer's Yeast Cell Wall on Fecal Steroid Excretion in Rats
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概要
- 論文の詳細を見る
To reveal the mechanism(s) of the cholesterol-lowering effect of brewer’s yeast cell wall (BYC), we examined the effect of BYC on fecal steroid excretion in rats fed a high-cholesterol and -fat (HCF) diet or a cholesterol-free standard (STD) diet. Male Sprague-Dawley rats were fed an HCF diet or an HCF diet supplemented with 5% or 10% BYC for 14 days. The addition of BYC to the HCF diet dose-dependently reduced the increment of serum total cholesterol concentration and increased the fecal bile acid and neutral steroid(cholesterol and coprostanol) excretion levels. In this experiment, a negative correlation between serum total cholesterol concentration and fecal bile acid excretion level was observed; however, a correlation between serum total cholesterol concentration and fecal neutral steroid excretion level was not observed. Next, male Sprague-Dawley rats were fed an STD diet or an STD diet supplemented with 5% or 10% BYC for 14 days, to investigate whether BYC could lower serum total cholesterol concentration in the rats with normal serum cholesterol concentrations. The addition of BYC to the STD diet also slightly increased the fecal bile acid excretion level; however, it did not affect the serum cholesterol concentration. Furthermore, we examined whether BYC can reduce the serum total cholesterol concentration in Sprague-Dawley rats fed an HCF diet prior to the administration of BYC, to increase the serum total cholesterol concentration. In this experimental model, BYC reduced serum total cholesterol concentration and increased fecal total steroid excretion level, and a negative correlation between serum total cholesterol concentration and fecal bile acid excretion level was observed. These results suggest that BYC reduces serum total cholesterol concentration by increasing fecal bile acid excretion level.
- 日本油化学会の論文
- 2002-05-01
著者
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Shimasaki Hiroyuki
Department of Health and Nutrition, University of Human Arts and Sciences
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Nakamura Tomohiko
キリンビール
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Shimasaki H
Teikyo Univ. School Of Medicine Tokyo Jpn
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Nakamura Tomohiko
Applied Bioresearch Center Corporate Research And Development Division Kirin Brewery Co. Ltd.
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Nakamura Tomohiko
Applied Bioresearch Center Research And Development Department Kirin Brewery Co. Ltd.
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Nakamura Tomohiko
Applied Bioresearch Center Corporate Research And Development Department Kirin Brewery Co. Ltd.
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HITOMI Yoshitaka
Applied Bioresearch Center, Corporate Research and Development Department, Kirin Brewery Co., Ltd.
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YOSHIDA Michiko
Applied Bioresearch Center, Corporate Research and Development Department, Kirin Brewery Co., Ltd.
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SHIRASU Yoshiharu
Applied Bioresearch Center, Corporate Research and Development Department, Kirin Brewery Co., Ltd.
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MIZUTANI Mai
Applied Bioresearch Center, Research and Development Department, Kirin Brewery Co., Ltd.
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Shimasaki Hiroyuki
Department Of Biochemistry Teikyo University School Of Medicine
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Shirasu Y
Applied Bioresearch Center Research And Development Department Kirin Brewery Co. Ltd.
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Mizutani Mai
Applied Bioresearch Center Research And Development Department Kirin Brewery Co. Ltd.
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Shimasaki Hiroyuki
帝京大医第一生化
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Mizutani Mai
Applied Bioresearch Center Corporate Research And Development Department Kirin Brewery Co. Ltd.
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Shimasaki H
Dep. Of Health And Nutrition Univ. Of Arts And Sciences
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Hitomi Yoshitaka
Applied Bioresearch Center Research And Development Department Kirin Brewery Co. Ltd.
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Yoshida M
Applied Bioresearch Center Research And Development Department Kirin Brewery Co. Ltd.
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Shirasu Yoshiharu
Applied Bioresearch Center Corporate Research And Development Department Kirin Brewery Co. Ltd.
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