Effects of Chronic Betaine Ingestion on Methionine-Loading Induced Plasma Homocysteine Elevation in Rats

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概要

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• The effects of chronic betaine ingestion were investigated in rats. Rats were fed an experimental diet containing 5% betaine for 4wk and methionine was intravenously administered. The elevations of plasma homocysteine were assessed by comparing the increments to the initial measured value and the positive incremental area under the plasma homocysteine concentration curve over the 240-min post-methionine-loading period (ΔAUC_<0-240>). In the betaine-ingesting rats, ΔAUC_<0-240> was significantly lower than in the control group (48% of the control), and the increments of plasma homocysteine were also lower compared with the control, especially 15-30 min after methionine loading. Choline, a precursor of betaine, did not alter the plasma homocysteine elevation. In a definite period immediately after methionine loading, carnitine, a methyl-group-rich amino acid, induced a significant increase of plasma homocysteine, compared to the control. Moreover, plasma homocysteine concentration was significantly decreased by 4wk of betaine ingestion. Betaine enhanced liver BHMT activity whereas choline and carnitine did not show any effects on BHMT activity. These results suggest that betaine contributes to both the decrease in the plasma homocysteine concentration and the suppression of plasma homocysteine elevation through the activation of liver BHMT.

• 日本ビタミン学会の論文

著者

• Shigematsu Norihiro

  Central Research Laboratory Fancl Corporation

• Shigematsu Norihiro

  Central Research Laboratory Panel Co.

• Nakata Rieko

  Department Of Food Science And Nutrition Nara Women's University

• Yagisawa Masako

  Central Research Laboratory Panel Co.

• SHIGEMATSU Norihiro

  Central laboratory, FANCL Corporation

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