Effects of Chronic Betaine Ingestion on Methionine-Loading Induced Plasma Homocysteine Elevation in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effects of chronic betaine ingestion were investigated in rats. Rats were fed an experimental diet containing 5% betaine for 4wk and methionine was intravenously administered. The elevations of plasma homocysteine were assessed by comparing the increments to the initial measured value and the positive incremental area under the plasma homocysteine concentration curve over the 240-min post-methionine-loading period (ΔAUC_<0-240>). In the betaine-ingesting rats, ΔAUC_<0-240> was significantly lower than in the control group (48% of the control), and the increments of plasma homocysteine were also lower compared with the control, especially 15-30 min after methionine loading. Choline, a precursor of betaine, did not alter the plasma homocysteine elevation. In a definite period immediately after methionine loading, carnitine, a methyl-group-rich amino acid, induced a significant increase of plasma homocysteine, compared to the control. Moreover, plasma homocysteine concentration was significantly decreased by 4wk of betaine ingestion. Betaine enhanced liver BHMT activity whereas choline and carnitine did not show any effects on BHMT activity. These results suggest that betaine contributes to both the decrease in the plasma homocysteine concentration and the suppression of plasma homocysteine elevation through the activation of liver BHMT.
- 日本ビタミン学会の論文
著者
-
Shigematsu Norihiro
Central Research Laboratory Fancl Corporation
-
Shigematsu Norihiro
Central Research Laboratory Panel Co.
-
Nakata Rieko
Department Of Food Science And Nutrition Nara Women's University
-
Yagisawa Masako
Central Research Laboratory Panel Co.
-
SHIGEMATSU Norihiro
Central laboratory, FANCL Corporation
関連論文
- Comparative Effect of Repeated Ingestion of Difructose Anhydride III and Palatinose on the Induction of Gastrointestinal Symptoms in Humans
- Evidence Suggesting That Difructose Anhydride III Is an Indigestible and Low Fermentable Sugar during the Early Stages after Ingestion in Humans
- Absorptive activity of calcium in the isolated cecal epithelium adaptively increased by 2 week's feeding of difructose anhydride III in rats.
- Effects of Long-term Administration of Garcinia cambogia extract on Visceral Fat Accumulation in Humans: A Placebo-controlled Double Blind Trial〔和文〕
- Effect of Administration with the Extract of Gymnema sylvestre R. Br Leaves on Lipid Metabolism in Rats
- Effect of Long Term-Administration with Gymnema sylvestre R.B_R on Plasma and Liver Lipid in Rats
- (-)-Hydroxycitrate Ingestion Increases Fat Oxidation during Moderate Intensity Exercise in Untrained Men(Food & Nutrition Science)
- Facile Degradation of Apolipoprotein B by Radical Reactions and the Presence of Cleaved Proteins in Serum
- Safety of Garcinia cambogia Extract in Healthy Volunteers : High-Dose Administration Study II
- Safety of Garcinia cambogia Extract in Healthy Men: High-Doses Administration Study I
- No-Observed-Adverse-Effect level (NOAEL) and Sequential-High-Doses Administration Study on Garcinia cambogia Extract in Humans
- Functional Expression of Miraculin, a Taste-Modifying Protein in Escherichia Coli
- Effects of Chronic Betaine Ingestion on Methionine-Loading Induced Plasma Homocysteine Elevation in Rats
- Citronellol and Geraniol, Components of Rose Oil, Activate Peroxisome Proliferator-Activated Receptor α and γ and Suppress Cyclooxygenase-2 Expression
- Current Problems of food intake in young women in Japan : Their influence on female reproductive function
- Determination of Folate Derivatives in Rat Tissues during Folate Deficiency
- Recent Advances in the Study on Resveratrol
- Evaluation of Food-derived Functional Ingredients According to Activation of PPAR and Suppression of COX-2 Expression
- Evaluation of Food-derived Functional Ingredients According to Activation of PPAR and Suppression of COX-2 Expression