Clorgyline Inhibits Orexin-A-Induced Arousal in Layer-Type Chicks
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概要
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We previously demonstrated that intracerebroventricular (ICV) injection of orexin-A induces arousal and increased metabolic turnover rates of norepinephrine, dopamine, and serotonin in layer (egg-type) chicks. Because monoamine oxidase-A (MAO-A) is a potent degrading enzyme of these monoamines, we hypothesized that orexin-A may mediate its arousal-inducing effects through MAO-A. Therefore, we simultaneously injected clorgyline, a specific inhibitor of MAO-A, with orexin-A and measured behavior of chicks. Behaviors associated with arousal were attenuated in the group of chicks that received clorgyline and orexin-A compared to those that received orexin-A alone. For the monoamine turnover rate, enhanced turnover rate of serotonin by orexin-A was attenuated by clorgyline. Therefore, we conclude that orexin-A-induced arousal is dependent upon monoamine neural activities stimulated by MAO-A in chicks.
- 社団法人 日本獣医学会の論文
著者
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FURUSE Mitsuhiro
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenviron
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Furuse Mitsuhiro
Laboratory Of Advanced Animal And Marine Bioresources Faculty Of Agriculture Kyushu University
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KATAYAMA Sachiko
Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironme
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SHIGEMI Kazutaka
Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironme
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CLINE Mark
Department of Biology, Radford University
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FURUSE Mitsuhiro
Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
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Katayama Sachiko
Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
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Shigemi Kazutaka
Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
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