A Patient with Advanced Hepatocellular Carcinoma Treated with Sorafenib Tosylate Showed Massive Tumor Lysis with Avoidance of Tumor Lysis syndrome
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概要
- 論文の詳細を見る
A 33-year-old man presented with pain and palsy of the leg in 2008 for treatment of hepatocellular carcinoma with huge distant metastases. The patient's tumors had slowly enlarged despite several treatments. Oral administration of sorafenib at 800 mg/day with careful observation was commenced in 2009. Laboratory investigations on day 7 showed massive tumor lysis. An abdominal CT showed multiple low density areas and tumor markers decreased, indicating extended tumor necrosis. In conclusion, clinicians should bear in mind not only the published adverse effects, but also massive tumor lysis, when treating patients with large tumor burden by sorafenib.
- JAPAN SOC INTERNAL MEDICINEの論文
著者
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Kobayashi Satoshi
Department of Aging Medicine and Geriatrics, Shinshu University, Graduate School of Medicine
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TANAKA Eiji
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate Sch
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MATSUMOTO AKIHIRO
Department of Urology, Graduate School of Medicine, Chiba University, and Chiba University Hospital
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Kamijo Atsushi
Department of Otorhinolaryngology, Head and Neck Surgery, Interdisciplinary Graduate School of Medic
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Umemura Takeji
Department Of Internal Medicine Shinshu University School Of Medicine
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Komatsu Michiharu
信州大学 医学部内科学
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Komatsu Michiharu
Division Of Gastroenterology Department Of Internal Medicine Shinshu University School Of Medicine
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Tanaka Eiji
Shinshu Univ. School Of Medicine Matsumoto Jpn
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Tanaka Eiji
Department Of Digestion And Cardiovascular Medicine University Of Tokushima
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Joshita Satoru
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Me
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Yoshizawa Kaname
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Me
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Sano Kenji
Department of Laboratory Medicine, Shinshu University Hospital
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Sekiguchi Tomohiro
Department of Clinical Training Center, Shinshu University Hospital
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Morita Susumu
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Me
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Komatsu Michiharu
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Me
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Ichijo Tetsuya
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Me
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Matsumoto Akinori
Third Department Of Internal Medicine Asahikawa Medical College
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Ichijo Tetsuya
信州大学 医学部内科学第二講座
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Sano Kenji
Department Of Laboratory Medicine Shinshu University School Of Medicine
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Umemura Takeji
Department Of Gastroenterology Shinshu University School Of Medicine
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Matsumoto Akihiro
Department Of Gastroenterology Shinshu University School Of Medicine
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Yoshizawa Kaname
Department Of Gastroenterology Shinshu University School Of Medicine
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Ichijo Tetsuya
Department Of Gastroenterology Shinshu University School Of Medicine
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Matsumoto Akihiro
Department Of Cardiothoracic Surgery The University Of Tokyo
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Joshita Satoru
Department Of Gastroenterology Shinshu University School Of Medicine
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Sano Kenji
Section Of Laboratory Medicine Shinshu University Hospital
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Komatsu Michiharu
Department Of Gastroenterology Shinshu University School Of Medicine
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Tanaka Eiji
Division Of Gastroenterology Department Of Internal Medicine Shinshu University School Of Medicine
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Sano Kenji
Department Of Laboratory Medicine School Of Medicine Shinshu University
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Sano Kenji
Department Of Applied Chemistry Faculty Of Engineering Toyama University
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Tanaka E
Department Of Medicine Shinshu University School Of Medicine
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Morita Susumu
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine
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Tanaka Eiji
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine
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Umemura Takeji
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine
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Joshita Satoru
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine
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Kamijo Atsushi
Department of Internal Medicine, Matsumoto Medical Center
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Matsumoto Akihiro
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine
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Ichijo Tetsuya
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine
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Kamijo Atsushi
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine
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Yoshizawa Kaname
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine
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Komatsu Michiharu
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine
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Kobayashi Satoshi
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine
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