A Grammatical Approach to the Alignment of Structure-Annotated Strings(Automata and Formal Language Theory)

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In this paper, we are concerned with a structural ambiguity problem of tree adjoining grammars (TAGs), which is an essential problem when we try to model consensus structures of given set of ribonucleic acid (RNA) secondary structures by TAGs. RNA secondary structures can be represented as strings with structural information, and TAGs have a descriptive capability of this kind of strings, what we call structure-annotated strings. Thus, we can model RNA secondary structures by TAGs. It is sufficient to use existing alignment methods for just computing the optimal alignment between RNA secondary structures. However, when we also want to model the resulting alignment by grammars, if we adopt these existing methods, then we may fail in modeling the alignment result by grammars. Therefore, it is important to introduce a new alignment method whose alignment results can be appropriately modeled by grammars. In this paper, we will propose an alignment method based on TAG's derivations each corresponding to a given RNA secondary structure. For an RNA secondary structure, there exist a number of derivations of TAGs which correspond to the structure. From the grammatical point of view, the property of TAGs drives us to the question how we should choose a derivation from these candidates in order to obtain an optimal alignment. This is the structural ambiguity problem of TAGs, which will be mainly discussed in this paper. For dealing with this problem appropriately, we will propose an edit distance between two structure-annotated strings, and then present an algorithm which computes an optimal alignment based on the edit distance.
一般社団法人電子情報通信学会の論文
2005-12-01

A Grammatical Approach to the Alignment of Structure-Annotated Strings(Automata and Formal Language Theory)

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