Quantitative Analysis of Water Dispersion Conditions and Pressure Transmission Characteristics of a Wet Kneaded Mass
スポンサーリンク
概要
- 論文の詳細を見る
In our previous paper[Watano S.et al., J.Powder Technology Japan, 37, 362-370(2000)], a novel compaction tester was developed to quantitatively evaluate the water dispersion condition of a wet kneaded mass prepared by a paddle type kneader. It has been demonstrated that the physical properties of pellets prepared by extrusion granulation after the kneading can be well predicted by the pressure transmission obtained through the compaction tester. This paper describes a more detailed investigation of the water dispersion, its mechanism and pressure transmission characteristics of wet kneaded masses prepared under various operating conditions. First, kneading by a paddle type kneader was conducted to prepare wet masses under various binder contents using different additional methods and different starting materials. Secondly, water dispersion and pressure transmission characteristics of wet masses were investigated. After the wet kneading, the wet kneaded masses were extruded through a dome type extruder and were dried by a fluidized bed to prepare dry pellets. The relationship between water dispersion and pressure transmission can be expressed by a single line, regardless of binder content or methods of addition. This implies that these parameters have no effect on the water dispersion condition of the wet kneaded mass prepared by a high shear paddle type kneader. Different water dispersion characteristics and the mechanism obtained by different starting materials can also be evaluated by the pressure transmission data. Properties of dry pellets can also be predicted by the pressure transmission. It can be concluded that the developed compaction tester can quantitatively evaluate the water dispersion condition of a wet kneaded mass and also predict properties of the final extruded products.
- 公益社団法人日本薬学会の論文
- 2001-01-01
著者
-
Watano S
Osaka Prefecture University
-
Watano Satoru
Department Of Chemical Engineering Osaka Prefecture University
-
Watano Satoru
Department Of Chemical Engineering Graduate School Of Engineering Osaka Prefecture University
-
Ohnishi Yasuharu
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
-
YASUTOMO Teruhito
Taiho Pharmaceutical Co., Ltd.
-
OSAKO Yoshifumi
Research and Development Department, Fuji Paudal Co., Ltd.
-
Ohnishi Y
Pharmaceutical Research Lab. Taiho Pharmaceutical Co. Ltd.
-
FURUKAWA JYUNPEI
Department of Chemical Engineering, Osaka Prefecture University
-
YASUTOMO Teruhito
Control Department, Taiho Pharmaceutical Co., Ltd.
-
Furukawa Jyunpei
Department Of Chemical Engineering Osaka Prefecture University
-
Yasutomo Teruhito
Control Department Taiho Pharmaceutical Co. Ltd.
関連論文
- HPLC Analysis of Juzen-taiho-to and Its Variant Formulations and Their Antimetastatic Efficacies
- Expression of the Anti-metastatic Effect Induced by Juzen-taiho-to is Based on the Content of Shimotsu-to Constituents
- Oral Administration of a Kampo (Japanese Herbal) Medicine Juzen-taiho-to Inhibits Liver Metastasis of Colon 26-L5 Carcinoma Cells
- Anti-metastatic and immunomodulating Properties of the Water Extract from Celosia argentea Seeds
- Improvement of Dissolution Property of Poorly Water-Soluble Drug by Supercritical Freeze Granulation
- Improvement of Dissolution Property of Poorly Water-Soluble Drug by Novel Dry Coating Method Using Planetary Ball Mill
- Removal of Fine Powders from Film Surface. I. Effect of Electrostatic Force on the Removal Efficiency
- Inhibitory Effect of a Traditional Chinese Medicine, Juzen-taiho-to, on Progressive Growth of Weakly Malignant Clone Cells Derived from Murine Fibrosarcoma
- Scale-Up of High Shear Granulation Based on Agitation Power
- Scale-Up of High Shear Granulation Based on the Internal Stress Measurement
- Scale-Up of Wet Kneading in a Novel Vertical High Shear Kneader
- Optimization and validation of an image processing system in fluidized bed granulation
- IR absorption characteristics of an IR moisture sensor and mechanism of water transfer in fluidized bed granulation
- Control Granule Growth in Fluidized Bed Granulation by an Image Processing System
- Measurement of Moisture Content by IR Sensor in Fluidized Bed Granulation. Effects of Operating Variables on the Relationship between Granule Moisture Content and Absorbance of IR Spectra
- Control of moisture content by adaptive fuzzy control in agitation fluidized bed granulation
- APPLICATION OF FUZZY LOGIC TO MOISTURE CONTROL IN FLUIDIZED BED GRANULATION
- Heat Transfer and the Mechanism of Drying in Agitation Fluidized Bed
- EFFECT OF GINSENG RADIX ON GLUT2 PROTEIN CONTENT IN MOUSE LIVER IN NORMAL AND EPINEPHRINE-INDUCED HYPERGLYCEMIC MICE
- Development of a Novel Compression Tester and Rheo-Mechanical Properties of Wet-Mass Powder.II : Effect of Moisture Content on the Rheo-Mechanical Properties
- Development of a Novel Compression Tester and Rheo-Mechanical Properties of Wet-Mass Powder.I : Effect of Kneading Time on the Rheo-Mechanical Properties
- A Comparative Study of High-Fat Diet Containing Fish Oil or Lard on Blood Glucose in Genetically Diabetic(db/db)Mice
- Novel mechanochemical process for synthesis of magnetite nanoparticles using coprecipitation method
- Granulation of Core Particles Suitable for Film Coating by Agitation Fluidized Bed III : Effect of Scale, Agitator Rotational Speed and Blade Shape on Granule Properties and Development of a High Accuracy Scale-Up Theory
- Granulation of Core Particles Suitable for Film Coating by Agitation Fluidized Bed II. : A Proposal of a Rapid Dissolution Test for Evaluation of Bitter Taste of Ibuprofen
- Granulation of Core Particles Suitable for Film Coating by Agitation Fluidized Bed I. Optimum Formulation for Core Particles and Development of a Novel Friability Test Method
- Surface Modification of Food Fiber by Dry Particle Coating
- Numerical Simulation of Film Coating Process in a Novel Rotating Fluidized Bed
- Scale-Up of Agitation Fluidized Bed Granulation by Neural Network
- Scale-Up of Agitation Fluidized Bed Granulation. V. Effect of Moisture Content on Scale-Up Characteristics
- Quantitative evaluation of kneading and extrusion processes by pressure transmission characteristics of wet kneaded masses
- On-line Monitoring of Granule Growth in High Shear Granulation by an Image Processing System
- Modeling of Agitation Fluidized Bed Granulation by Random Coalescence Model
- Heat Transfer and Granule Growth Rate in Fluidized Bed Granulation
- Mathematical Model in the Kinetics of Agitation Fluidized Bed Granulation. Effects of MOisture Content, Damping Speed and Operation Time on Granule Growth Rate
- COMPUTER SIMULATION OF AGITATION FLUIDIZED BED GRANULATION BY A TWO-DIMENSIONAL RANDOM ADDITION MODEL
- COMPUTER SIMULATION OF FLUIDIZED BED GRANULATION BY A TWO-DIMENSIONAL RANDOM COALESCENCE MODEL
- Drying of Granules in Agitation Fluidized Bed
- Development of a novel particle size control system for hammer milling
- Determination of Optimal Formulation for Extrusion Granulation by Compression Test of Wet Kneaded Mass
- Development of a Novel Vertical High Shear Kneader and Its Performance in Wet Kneading of Pharmaceutical Powders
- Quantitative Analysis of Water Dispersion Conditions and Pressure Transmission Characteristics of a Wet Kneaded Mass
- A method for process monitoring and determination of operational end-point by frequency analysis of power consumption in agitation granulation
- Removal of Fine Powders from Film Surface. II. Effect of Operating Parameters on the Removal Efficiency
- Scale-up methodology for tumbling ball mill based on impact energy of grinding balls using discrete element analysis
- Continuous Monitoring and Mechanism of Electrostatic Charge of Powder in Fluidized Bed Process
- Effect of Spray Mist Size on the Properties of Granules Prepared by Agitation Fluidized Bed Coating
- Preparation of Core Particles for Aqueous Film Coating Using Agitation Fluidized Bed
- Prediction of Granule Physical Property by a Novel Compression Energy of Wet Powder
- Anomalous arrangement of pancreaticobiliary ductal system associated with cholangiocellular carcinoma
- Development of a Novel Granular Detergent by Inorganic Solution Binder
- A Comparative Study of High-Fat Diet Containing Fish Oil or Lard on Blood Glucose in Genetically Diabetic (db/db) Mice
- Development of a Novel Granular Detergent with an Interspersion Particle Comprising an Anionic Surfactant and a Polymeric Polycarboxalate
- Development of a High Active Surfactant and High Soluble Granular Detergent by Secondary Alkyl Sulfate
- Monitoring and Scale-Up of Static Electrification during Solid-Liquid Mixing
- Rheological Analysis and Quantitative Evaluation of Wet Kneaded Wax Matrix
- Measurement of Physical Strength of Pharmaceutical Extruded Pellets
- Development of a Novel Tablet Machine for a Tiny Amount of Powder and Evaluation of Capping Tendency
- In-Die Evaluation of Capping Tendency of Pharmaceutical Tablets Using Force-Displacement Curve and Stress Relaxation Parameter
- My impression of APT2000
- Control of moisture content in fluidized bed granulation by neural network.