Scale-Up of Wet Kneading in a Novel Vertical High Shear Kneader
スポンサーリンク
概要
- 論文の詳細を見る
A novel multi-functional vertical high shear kneader has been developed and its performance in wet kneading has previously been reported [Watano et al., Chem. Pharm. Bull., 50 (3), 341-345 (2002)]. In this study, scale-up of wet kneading in the novel vertical high shear kneader was conducted. Pharmaceutical excipients composed of lactose, cornstarch and micro-crystalline cellulose were used as powder samples. Kneading operations were conducted under various operating conditions and three different vessel scales. The dried pellets were then prepared by extruding the wet kneaded masses through a dome-type extruder and their drying by a fluidized bed. The physical properties such as strength and disintegration time of the dried pellets were evaluated. It was found that the properties of the dried pellets and their scale-up characteristics were well expressed by an agitation power per unit vessel volume and dimensionless Froude number.
- 公益社団法人日本薬学会の論文
- 2005-01-01
著者
-
佐藤 美洋
北海道大学大学院薬学研究院
-
関川 善夫
Department Of Pharmaceutical Sciences National Institute Of Public Health
-
Sato Y
Osaka Prefecture University
-
Watano S
Osaka Prefecture University
-
Watano Satoru
Department Of Chemical Engineering Osaka Prefecture University
-
Sato Y
(present Address)tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
-
Sato Y
Kyoritsu College Of Pharmacy
-
SATO YOSHINOBU
Osaka University
-
Ohnishi Yasuharu
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
-
OKAMOTO Takumi
Osaka Prefecture University
-
WATANO Satoru
Osaka Prefecture University
-
OSAKO Yoshifumi
Fuji Paudal Co., Ltd.
-
OHNISHI Yoshito
Taiho Pharmaceutical Co., Ltd.
-
YASUTOMO Teruhito
Taiho Pharmaceutical Co., Ltd.
-
佐藤 嘉信
Department Of Chemical Engineering University Of Osaka Prefecture
-
Ohnishi Y
Pharmaceutical Research Lab. Taiho Pharmaceutical Co. Ltd.
-
Yasutomo Teruhito
Control Department Taiho Pharmaceutical Co. Ltd.
関連論文
- ルテナシクロペンテン中間体を経由するエンインの新規環化反応の開発
- A New Strategy for Lung Cancer Treatment : Impact of Real-Time Navigation on Thoracoscopic Surgery
- HPLC Analysis of Juzen-taiho-to and Its Variant Formulations and Their Antimetastatic Efficacies
- Expression of the Anti-metastatic Effect Induced by Juzen-taiho-to is Based on the Content of Shimotsu-to Constituents
- Oral Administration of a Kampo (Japanese Herbal) Medicine Juzen-taiho-to Inhibits Liver Metastasis of Colon 26-L5 Carcinoma Cells
- Anti-metastatic and immunomodulating Properties of the Water Extract from Celosia argentea Seeds
- Thermodynamic Effects of Hopanoids on Synthetic and Bacterial Phospholipid Membranes
- Interactions between Bacteriohopane-32,33,34,35-tetrol and Liposomal Membranes Composed of Dipalmitoylphosphatidylcholine
- ATOMIC FORCE MICROSCOPY OF DIMYRISTOYLPHOSPHATIDYLCHOLINE MEMBRANES
- Synthesis and Hypnotic and Anti-Human Immunodeficiency Virus-1 Activities of N^3-Substituted 2'-Deoxy-2'-fluorouridines