ニッケル触媒を用いた[2+2+2]環化反応の開発とその応用
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概要
- 論文の詳細を見る
A nickel(0)-catalyzed asymmetric[2+2+2] cocyclization has been realized for the first time. This reaction involves conceptually new enantiotopic group selective formation of a nickelacyclopentadiene intermediate and produces an isoindoline derivative (73% ee, 78% conv.yield) and an isoquinoline derivative(54% ee, 62% yield) having benzylic chiral carbon centers. The synthesizing methods of biaryls using the nickel-catalyzed[2+2+2] cocyclization were also developed. Two ways for the synthesis of biaryl using [2+2+2] cocyclization were investigated : one method is that biaryls synthesized from alkyne having a phenyl group and 2 equivalents of acetylene, and the other method is that those were synthesized from α, ω-diyne having a phenyl group at the α-position and acetylene.
- 公益社団法人日本薬学会の論文
- 2001-12-01
著者
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佐藤 美洋
北海道大学大学院薬学研究院
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関川 善夫
Department Of Pharmaceutical Sciences National Institute Of Public Health
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Sato Y
Osaka Prefecture University
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Sato Y
(present Address)tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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Sato Y
Kyoritsu College Of Pharmacy
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佐藤 嘉信
Department Of Chemical Engineering University Of Osaka Prefecture
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