OXYGENATED STEROLS AS INHIBITORS OF ENZYMATIC CONVERSION OF DIHYDROLANOSTEROL INTO CHOLESTEROL
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概要
- 論文の詳細を見る
Seven oxygenated sterols were tested for their effect on cholesterol biosynthesis from 24,25-dihydrolanosterol by rat hepatic subcellular 10000 x g supernatant fraction. The sterols (40 μM) exhibited considerable inhibitory effects on the synthesis of cholesterol from [24,25-^3H]-24,25-dihydrolanosterol (18 μM). 5α-Cholest-8 (14)-en-3β-ol-15-one had the greatest effect (64% inhibition). The biological importance of the inhibitory properties of the sterols is discussed.
- 公益社団法人日本薬学会の論文
- 1984-08-25
著者
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佐藤 良博
共立薬科大学名誉
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園田 よし子
Kyoritsu College of Pharmacy
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佐藤 良博
Kyoritsu College of Pharmacy
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池川 信夫
東京工業大学
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池川 信夫
Department Of Chemistry Tokyo Institute Of Technology
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森崎 益雄
共立薬大
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森崎 益雄
Department of Chemistry, Tokyo Institute of Technology
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