Effects of Cholesterol Analogs on Cholesterol Biosynthesis from Lanosterol
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概要
- 論文の詳細を見る
Cholesterol biosynthesis was examined with rat hepatic subcellular 10000×g supernatant fraction incubated with [24-^3H]-lanosterol in the presence of one of twelve cholesterol analogs (1-12) including sitosterol. Cholesterol analogs (40μM) with different sizes of side chains exhibited very minor inhibitory effects (2-7%) compared with that of cholesterol (21%) on the synthesis of cholesterol from [24-^3H]-lanosterol (18μM). The structure-inhibitory activity relationship of cholesterol analogs is discussed.
- 公益社団法人日本薬学会の論文
- 1983-05-25
著者
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佐藤 良博
共立薬科大学名誉
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園田 よし子
Kyoritsu College of Pharmacy
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佐藤 良博
Kyoritsu College of Pharmacy
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池川 信夫
東京工業大学
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池川 信夫
Department Of Chemistry Tokyo Institute Of Technology
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森崎 益雄
共立薬大
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