Metabolism of 27-Nor-24,25-dihydrolanosterol and 23,24,25,26,27-Pentanordihydrolanosterol by Rat Liver Homogenate Preparations
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The metabolism of 27-nor-24,25-dihydrolanosterol (1) which is an effective inhibitor of cholesterol biosynthesis from lanosterol was studied using the unlabeled and 24,25-tritiated compounds. 1 was transformed into the cholesterol analog, 27-norcholesterol, to the extent of 6.5% by incubation with rat liver homogenate under conditions such that lanosterol in the control experiment was converted to cholesterol to the extent of 24.8%. The structures of two other metabolites (9 and 11) were determined. On the other hand, 23,24,25,26,27-pentanordihydrolanosterol (2), which is also an inhibitor, was not transformed into the corresponding cholesterol analog, suggesting the importance of the side chain structure of lanosterol in cholesterol biosynthesis.
- 公益社団法人日本薬学会の論文
- 1982-02-25
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