Regio- and Stereoselective Hydrogenation of 2'-Demethoxy-2'-methyldehydrogriseofulvin, a Symmetrical Substrate, to (+)-2'-Demethoxy-2'-methylgriseofulvin with a Cell-Free System of Streptomyces cinereocrocatus
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概要
- 論文の詳細を見る
Enzymatic hydrogenation of 2'-demethoxy-2'-methyldehydrogriseofulvin (5) with a cell-free system of Streptomycs cinereocrocatus afforded (+)-2'-demethoxy-2'-methylgriseofulvin (6). The structure of 6 was determined on the basis of comparisons of the proton nuclear magnetic resonance spectrum, mass spectrum, and circular dichroism with those of a standard specimen which was synthesized chemically. The results demonstrated that when the 2'-position of (-)-dehydrogriseofulvin was substituted with a methyl group, its hydrogenation with the cell-free system occurred stereoselectively at the 5', 6'-position.
- 公益社団法人日本薬学会の論文
- 1990-02-25
著者
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佐藤 良博
共立薬科大学名誉
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小田 泰子
Kyoritsu College of Pharmacy
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佐藤 良博
Kyoritsu College of Pharmacy
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佐藤 良博
共立薬大
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橋本 文江
Kyoritsu College of Pharmacy
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