Inhibition of Transcription by Mammalian Ribouncleic Acid Polymerase II : Effects of Diethylstilbestrol and Its Analogues
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概要
- 論文の詳細を見る
We examined the effects of diethylstilbestrol (1), Z, Z-dienestrol (2), E, E-dienestrol (3), indenestrol A (4), indenestrol B (5) and estradiol (6) on the activity of in vitro accurate transcription from adenovirus 2 major late promoter by mammalian ribonucleic acid (RNA) polymerase II using partially purified transcription factors from HeLa cell nuclear extract as well as on RNA polymerase II activity assayed for random incorporation of ribonucleotides. 1,2,and 3 inhibited both activities, whereas 4 and 5 were inhibitory only in the transcription activity at concentrations higher than 10 μg/ml. However 6 had no effects on both activities.
- 公益社団法人日本薬学会の論文
- 1991-10-25
著者
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佐藤 良博
共立薬科大学名誉
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小田 泰子
Kyoritsu College of Pharmacy
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佐藤 良博
Kyoritsu College of Pharmacy
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安河内 幸雄
Medical Research Institute Tokyo Medical And Dental University
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佐藤 良博
共立薬大
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北嶋 繁孝
Medical Research Institute Tokyo Medical And Dental University
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