Reaction of (20S)-3β-Acetoxybisnorchol-5-enic Acid with Lead Tetraacetate ; : Structure of Pregnane Derivatives and a Dimer
スポンサーリンク
概要
- 論文の詳細を見る
Reaction of 3β-acetoxybisnorchol-5-enic acid (1) with lead tetraacetate in benzene gave ⊿^20 and ⊿^<17 (20)> compounds (2a and 2b) and 20α-and 20β-acetoxy compounds (3a and 3b), with a trace of 20-keto compound (4) and a dimer (5). The structure of 5 was determined as 3'β-acetoxypregn-5'-en-20'α-yl 3β-acetoxybisnorchol-5-enate (Chart 1). The use of toluene or xylene in place of benzene resulted in decreased formation of 2b with the formation of the 17-ethyl compound (2c). The reactions were examined under various conditions (Table I) and the reaction mechanisms are discussed.
- 公益社団法人日本薬学会の論文
- 1982-03-25
著者
関連論文
- Solanum Alkaloids as Inhibitors of Enzymatic Conversion of Dihydrolanosterol into Cholesterol(Biological,Chemical)
- Synthesis of [21-^2H]- and [22-^2H]-Derivatives of 23,24,25,26,27-Pentanorcholesterol and 23,24,25,26,27-Pentanordihydrolanosterol and the Stereochemical Significance of the Deuterium Spin-Lattice Relaxation Times
- Evidence of Intercalation of trans-Diethylstillbestrol and Its Methyl Ether Derivatives in Multibilayers of Egg Phosphatidylcholine by High-Power Deuterium Nuclear Magnetic Resonance (^2H-NMR) Spectroscopy
- Microbial Transformation of (+)-and (-)-Dehydrogriseofulvin by Streptomyces Species Analyzed by ^2H Nuclear Magnetic Resonance Spectroscopy
- Stereochemistry of Microbial Hydrogenation of (-)-α-Santonin to (+)-1,2-Dihydro-α-santonin by Streptomyces cinereocrocatus NRRL 3443
- Structure of (+)-Epigriseofulvin
- 樹皮中に含まれる生理活性縮合型タンニン : 化学的性状, 酵素阻害, および抗植物ウイルス活性
- Inhibition of DNA of Topoisomerase I Activity by Diethylstilbestrol and Its Analogues
- Effects of Some Diethylstilbestrol Metabolites and Analogs on Cytotoxicity and Aneuploidy Induction in Chinese Hamster V79 Cells
- Effects of 3,3'-dihydroxy-α, β-diethylstilbene and 3,3', 4,5'-Tetrahydroxystilbene on Microtubule Assembly in Vitro, Aneuploidy Induction, and Cellular Microtubule and Actin Networks
- Effect of Estradiol and Ethynylestradiol on Microtubule Distribution in Chinese Hamster V79 Cells
- Lanosterol 14α-Demethylase (Cytochrome P-450_) : Modulation of Its Enzyme Activity by Cholesterol Feeding
- Metabolism of 32-Oxo-24,25-dihydrolanosterols by Partially Purified Cytochrome P-450_ from Rat Liver Microsomes
- Metabolism of 24,25-Dihydrolanosterol Analogs by Partially Purified Cytochrome P-450_ from Rat Liver Microsomes
- Metabolism of 32-Hydroxylated 24,25-Dihydrolanosterols by Partially Purified Cytochrome P-450_ from Rat Liver Microsomes
- In Vitro Effects of Oxygenated Lanosterol Derivatives on Cholesterol Biosynthesis from 24,25-Dihydrolanosterol
- Dienone-Phenol Rearrangement of (+)-2'-Demethoxydehydrogriseofulvin into a 4-Methylxanthone Derivative
- OXYGENATED STEROLS AS INHIBITORS OF ENZYMATIC CONVERSION OF DIHYDROLANOSTEROL INTO CHOLESTEROL
- Effects of Cholesterol Analogs on Cholesterol Biosynthesis from Lanosterol
- ラノステロールからのコレステロール生合成に及ぼすラノステロールおよびコレステロール同族体の影響
- Relationship between Cytotoxic and Microtubule Disruptive Activities of (+)-, (-)-and (±)-Indenestrol A and B Monomethyl Ethers in Chinese Hamster V79 Cells in Culture
- Preparation of Monomethyl Ether Derivatives of (+)-, (-)- and (±)-Indenestrols A and B
- Optically Active trans-Diethylstilbestrol Oxide Monomethyl Ether
- Effects of 32-Oxygenated Lanosterol Derivatives on 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity and Cholesterol Biosynthesis from 24,25-Dihydrolanosterol
- Inhibition of Transcription by Mammalian Ribouncleic Acid Polymerase II : Effects of Diethylstilbestrol and Its Analogues
- Synthesis of Lanosterol Derivatives with a Functional Group at C-32,Including an Antineoplastic Sterol, 3β-Hydroxylanost-7-en-32-oic Acid
- Regio- and Stereoselective Hydrogenation of 2'-Demethoxy-2'-methyldehydrogriseofulvin, a Symmetrical Substrate, to (+)-2'-Demethoxy-2'-methylgriseofulvin with a Cell-Free System of Streptomyces cinereocrocatus
- GANODERIC ACID AND ITS DERIVATIVES AS CHOLESTEROL SYNTHESIS INHIBITORS
- Carbon-13 Nuclear Magnetic Resonance Study of meso-Hexestrol and Its Derivatives
- Non-stereoselective Conversion of the Four Diastereoisomers at the C-24 and C-25 Positions of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic Acid into Cholic Acid
- A Simplified Synthesis of 32-0xygenated Lanosterol Derivatives(Organic,Chemical)
- Synthesis of Lanosterol Analogs with Lengthened Side Chains and Their Effects on Cholesterol Biosynthesis from Lanosterol
- Effects of Oxygenated Lanosterol Analogs on Cholesterol Biosynthesis from Lanosterol
- Synthesis of (22R)- and (22S)-22-Hydroxylanosterols
- Reaction of (20S)-3β-Acetoxybisnorchol-5-enic Acid with Lead Tetraacetate ; : Structure of Pregnane Derivatives and a Dimer
- Metabolism of 27-Nor-24,25-dihydrolanosterol and 23,24,25,26,27-Pentanordihydrolanosterol by Rat Liver Homogenate Preparations
- Synthesis of Lanosterol Analogs with Modified Side Chains
- Effects of Lanosterol Analogs on Cholesterol Biosynthesis from Lanosterol
- Effects of Lanosterol Analogs on Cholesterol Biosynthesis from Lanosterol
- Synthesis of Lanosterol Analogs with Modified Side Chains
- The Hydrogenation of α-Hydroxymethylene-ketone Derivatives to α-Hydroxymethyl-ketone Derivatives with a Cell-Free System of Streptomyces cinereocrocatus
- Stereochemistry of Transformation of 5'-Formylgriseofulvin to 5'α-Hydroxymethylgriseofulvin with a Cell-Free System of Streptomyces cinereocrocatus
- Stereospecific Incorporation of Hydrogen from Reduced Nicotinamide Adenine Dinucleotide Phosphate in Hydrogenation of (-)-Dehydrogriseofulvin to (+)-Griseofulvin by a Partially Purified Enzyme System of Streptomyces cinereocrocatus
- Stereochemistry of Hydrogenation of (-)-Dehydrogriseofulvin to (+)-Griseofulvin with a Cell-Free System of Streptomyces cinereocrocatus
- Biosynthesis of Cholesterol from Lanosterol : Effect of Lanosterol Analogues on Cholesterol Biosynthesis from Lanosterol and their Metabolisms
- 7 LanosterolからのCholesterol生合成 : Lanosterol同族体の生合成に及ぼす影響とその代謝
- ラノステロールからのコレステロール生合成に及ぼすラノステロール同族体の影響
- (20S) および (20R)-3β-Acetoxybisnorchol-5-enic Acid の Pb (OAc)_4 との反応
- 3β-Acetoxy bisnorchol-5-enic Acid の Pb (OAc)_4 との反応によるステロイド二量体の生成とその構造
- 3β-Acetoxy-bisnorchol-5-enic Acid の Pb (OAc)_4 との反応