Anthraquinones from Neonauclea calycina and Their Inhibitory Activity against DNA Topoisomerase II

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概要

• 論文の詳細を見る

• In a series of searches fot DNA topoisomerase II inhibitors from naturally occurring compounds, a wood extract of Neonauclea calycina MERR. (Rubiaceae) showed a moderate effect in vitro. Purification of the extract resulted in the isolation of seven known anthraquinones. The structures were characterized as damnacanthal, rubiadin 1-methyl ether, nordamnacanthal, morindone, damnacanthol, lucidin 3-O-primeveroside and morindone 6-O-primeveroside by spectral analysis, respectively. Damnacanthal and morindone showed an intensive inhibitory effect against topoisomerase II (IC_<50> : 20μg/ml and 21μg/ml).

• 公益社団法人日本薬学会の論文
• 1998-06-15

著者

• TANAKA Toshiyuki

  Department of Urology, Osaka University Graduate School of Medicine

• IINUMA Munekazu

  Department of Pharmacognosy, Gifu Pharmaceutical University

• 土佐 秀樹

  岐阜薬大

• NOZAKI Hiroshi

  Department of Biological Chemistry, Faculty of Science, Okayama University of Science

• Tanaka Toshiyuki

  Gifu Prefectrual Inst. Health And Environmental Sci. Gifu Jpn

• Tsutsui Ken

  Department of Molecular Biology. Okayama University Medical School.

• Yamada Masayuki

  Department Of Polymer Chemistry Tokyo Institute Of Technology

• Naganawa H

  Department Of Biological Chemistry Faculty Of Science Okayama University Of Science

• Nozaki H

  Meiji Milk Products Co. Ltd. 26-11 Midori 1 Chime

• FUJIMORI Shiho

  Pharmaceuticals Development Department, Meiji Dairies Corporation

• YAMADA Masashi

  Meiji Dairies Corporation

• Asai Fujio

  Department of Pharmacognosy, Gifu Pharmaceutical University

• Tanaka Toshiyuki

  Department Of Endocrinology And Metabolism National Research Institute For Child Health And Developm

• Yamada M

  Division Of Protein Biosynthesis Institute For Protein Research Osaka University

• Asai Fujio

  Department Of Pharmacognosy Gifu Pharmaceutical University

• Ikeda Shougo

  Department Of Biological Chemistry Faculty Of Science Okayama University Of Science

• Tsutsui Ken

  Graduate School Of Medicine Dentistry And Pharmaceutical Science Okayama University

• Fujimori S

  Pharmaceuticals Development Department Meiji Dairies Corporation

• Yamada Masayoshi

  Meiji Dairies Corporation

• Tsutsui Kimiko

  Department Of Neuroanatomy/neurobiology Okayama University Graduate School Of Medicine Dentistry And

• Tsutsui Kimiko

  Department Of Neuroanatomy And Neurobiology Okayama University Graduate School Of Medicine Dentistry

• FUJIMORI Shiho

  Meiji Institute of Health Science, Meiji Milk Products Co., Ltd.,

• TOSA Hideki

  Department of Pharmacognosy, Gifu Pharmaceutical University

• Nozaki Hiroshi

  Department Of Biochemistry Faculty Of Science Okayama University Of Science

• 土佐 秀樹

  Department Of Pharmacognosy Gifu Pharmaceutical University

• Iinuma Munekazu

  Department Of Bioactive Molecutes Pharmacognosy Gifu Pharmaceutical University

• Tsutsui Ken

  Department Of Biochemistry Cancer Institute Okayama University Medical School

• Tanaka Toshiyuki

  Department Of Electronics And Information Engineering Tokyo Metropolitan University

• Nozaki Hiroshi

  Department Of Biochemistry Faculty Of Science

• Nozaki H

  Department Of Biological Chemistry Faculty Of Science Okayama University Of Science

• Tanaka Toshiyuki

  Department Of Applied Physics And Physico-informatics Keio University

• Tanaka Toshiyuki

  Department Of Applied Chemistry Faculty Of Engineering University Of Toyama

• Yamada Masashi

  Department Of Biological Chemistry Faculty Of Science Okayama University Of Science

• Tosa Hideaki

  Department Of Pharmacognosy Gifu Pharmaceutical University

• IINUMA Munekazu

  Department of Bioactive Molecules, Pharmacognosy, Gifu Pharmaceutical University

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