Changes in Erythrocyte Potassium Concentration in Goldblatt Hypertension of the Rabbit
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概要
- 論文の詳細を見る
Changes in potassium (K) concentration in erythrocytes (RBC) were investigated during the early developing stage (1 and 2 weeks after) and the chronic established stage (12 to 16 weeks after the renal artery constriction) in two-kidney (group 2H) and one-kidney Goldblatt hypertension (group 1H) of the rabbit. In both group 2H and group 1H, blood pressure was already elevated significantly during week 1, and reached a level about 70mmHg higher than the pre-constriction level at the chronic stage. It did not change in the control group (group C). During week 2, the change in RBC K concentration showed a significant negative correlation with the change in blood pressure in group 2H (r=-0.529, n=26, p<0.01). During the chronic stage, the RBC K concentration was lower in group 2H (103.5±1.7mEq/1 RBC, n=10, p<0.01 com-pared with group C) and in group 1H (102.1±1.6, n=7, p<0.001) than in group C (111.6±2.2, n=9). The change in this parameter from the pre-constriction value was -11.9±2.1mEq/l RBC (p<0.001) in group 2H, -13.0±1.8 (p<0.001) in group 1H, and -2.4±2.6 (not significant) in group C. The results suggest that the intracellular electrolyte metabolism is altered in both types of chronic Goldblatt hypertension.
- International Heart Journal刊行会の論文
著者
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TANAKA Toshiyuki
Department of Urology, Osaka University Graduate School of Medicine
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Seki Akira
Institute for Adult Diseases, Asahi Life Foundation
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Fujii Jun
Institute for Adult Diseases, Asahi Life Foundation
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FUJII JUN
3rd Department oflnternal Medicine. Faculty ofMedicine. University of Tokyo
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Seki Akira
Institute For Adult Disease Asahi Life Foundation
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Fjii Jun
Inst. Adult Dis. Asahi Life Foundation.
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Tanaka Toshiyuki
Department Of Endocrinology And Metabolism National Research Institute For Child Health And Developm
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Tanaka Toshiyuki
Department Of Medicine National Cardiovascular Center
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Seki Akira
3rd Dept. Of Internal Med. Tokyo University School Of Medicine.
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Fujii Jun
Institute For Adult Dis. Asalli Life Foudation
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Tanaka Toshiyuki
Department Of Electronics And Information Engineering Tokyo Metropolitan University
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Fujii Jun
The Institute For Adult Diseases Asahi Life Foundation.
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Tanaka Toshiyuki
Department Of Applied Chemistry Faculty Of Engineering University Of Toyama
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Fujii Jun
Institute For Adult Diseases Asahi Life Foundation Shinjuku
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Tanaka Toshiyuki
Department of Medicine, National Cardiovascular Center
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