High renin hypertension in the elderly.
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概要
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This paper describes clinical features of high renin hypertension in the elderly. Peripheral plasma renin activity ranged from 0 to 20.1ng/ml/hr in 59 hypertensive in-patients aged 70 to 86. The patients were divided into 2 groups: 9 cases with plasma renin activity greater than or equal to 3.0ng/ml/hr (high renin group) and the remaining 50 with plasma renin activity less than 3.0ng/ml/hr (control group). The development of hypertension differed between the 2 groups. Six of the high renin group (66.7%) had a history of acceleration of previously mild hypertension, while only 3 of the control group (6.0%) had this history (p<0.01). The frequencies of high diastolic blood pressure (greater than or equal to 120mmHg), massive proteinuria (at least 3.0g/day), hypokalemia (serum potassium less than or equal to 3.0mEq/L) and high serum cholesterol (greater than or equal to 250mg/100ml) were significantly greater in the high renin group than in the control group (p<0.01, respectively). Renovascular hypertension was suspected in 6 patients from the high renin group (66.7%), as compared with 1 of the control group (2.0%) (p<0.001). There was massive proteinuria in 3 of 6 patients with renovascular hypertension in the high renin group and 2 showed nephrotic syndrome. Thus, two-thirds of the elderly patients with high renin hypertension had probable renovascular hypertension with a history of rapid progression of hypertension.
- International Heart Journal刊行会の論文
著者
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Yamaoki Kazuhide
Third Dept. of Intern. Med. and Dep. of Radiology, Faculty of Med. Univ. of Tokyo
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SEKI Akira
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Fujii Jun
Institute For Adult Dis. Asalli Life Foudation
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AMANO Masao
Second Department of Internal Medicine, Gunma University
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TAKAYAMA Yoshiaki
Second Department of Internal Medicine, Gunma University
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YAMAOKI Kazuhide
Third Department of Internal Medicine, University of Tokyo
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