Experimental Production of Poststenotic Dilatation in the Carotid Arteries of Rabbits
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概要
- 論文の詳細を見る
Arterial dilatation distal to a stenosis has been known as poststenotic dilatation (PSD). This paper describes arterial constriction enough to produce PSD, time course of PSD, structural changes of the dilated segments and influence of hypertension on the development of PSD. These problems were studied in 2 experimental protocols. In protocol I, 87 carotid arteries of 45 rabbits were constricted by silver clip of 0.65 to 2.0mm in diameter. The arterial diameter was measured at the sites both proximal and distal to the constriction after 3 days to 8 weeks. In protocol II, 22 carotid arteries of 12 rabbits with experimental one-or two-kidney Goldblatt hypertension were constricted and the development of PSD was compared with age matched controls. Remarkable PSD developed in arteries with moderate stenosis of 45 to 60% constriction. The degree of dilatation expressed as ratio of distal to proximal diameter reached about 1.5 at the end of the second week and remained unchanged thereafter. Destrucion of the elastic fibers with intimal hyperplasia was observed in the dilated segments even at the early stages of the PSD. Both mild and severe stenosis failed to produce prominent PSD. In protocol II, the PSD averaged 1.18±0.05 (mean±SE) in hypertensive, and 1.32±0.03 in normotensive animals (p<0.05). The result suggests that chronic hypertension decreases the distensibility of the arteries
- International Heart Journal刊行会の論文
著者
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Imataka Kouji
Visiting Scientists From The Third Department Of Internal Medicine University Of Tokyo
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Tomono Shoichi
Second Department Of Internal Medicine Gunma University School Of Medicine
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SEKI Akira
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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TAKAHASHI Nobuo
Second Department of Internal Medicine, School of Medicine, Gunma University
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IMATAKA Kouji
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Fujii Jun
Institute For Adult Dis. Asalli Life Foudation
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TOMONO Shoichi
Second Department of Internal Medicine, Gumma University
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