69(P47) オトギリソウ科植物成分研究と生理活性(ポスター発表の部)
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概要
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The family Guttiferae includes about 50 genera and nearly 1000 species. Because many species in this pantropical family have been used as traditional medicine, Guttiferaeous plants are important natural resources to search for biologically active principles. The family is well-known to be an abundant container of prenylated xanthones, biflavonoids, coumarins and benzophenones. Recently, various bioactivities of xanthones and coumarins have been reported. From this stand point of view, we investigated the chemical constituents in Guttiferaeous plants along with their bioactivity. Chemical investigation Chemical constituents in Garcinia (5 species), Calophyllum (2), Mammea (1), Cratoxylum (1) and Harungana (1) species resulted in isolation eighty-five xanthones, five benzophenones, four anthraquinones, three anthranones, nine flavonoids and two coumarin derivatives, in addition to three benzophenone-xanthone dimers with a new skeleton. Among them, forty-nine isolates were new compounds. Anti-bacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) After the first screening for antibacterial activity of extracts prepared from Guttiferaeous plants anginst S. aureus NIHJ 209_p, we found the potent activity in the benzene extract of pericarps of Garcinia mangostana. The extract was bioassay-guidedly fractionated and purified to achieve some compounds with anti-MRSA activity. An active isolate, xanthone, α-mangostin (70), showed minimum inhibitory concentration (MIC) to be ranged from 1.57 to 12.5 μg/ml. Other xanthones isolated and characterized were determined their anti-MRSA activity. Rubraxanthone (78), which has a similar substitutional pattern as 70, from G. dioica, exhibited the highest activity against staphylococcal strains (MIC: 0.313-1.25μg/ml) among them and the activity was stronger than that of vancomycin (3.13-6.25μg/ml). On the other hand, benzophenone derivatives, xanthochymol (61) and garcinol (65) from the pericarps of G. subelliptica and G. purpurea, also showed the strong anti-MRSA activity (MIC: 3.13-12.5μg/ml). The concentration is nealy equal to that of vancomycin.
- 天然有機化合物討論会の論文
- 1996-09-02
著者
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伊藤 哲朗
岐阜薬大薬
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田中 稔幸
岐阜薬大薬
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飯沼 宗和
岐阜薬大薬
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伊藤 哲郎
岐阜薬大薬
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田中 稔幸
Department Of Pharmacognosy Gifu Pharmaceutical University
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土佐 秀樹
岐阜薬大
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浅井 藤雄
岐阜薬大
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田中 稔幸
岐阜薬大・生薬
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飯沼 宗和
岐阜薬科大学
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飯沼 宗和
Department Of Pharmacognosy Gifu Pharmaceutical University
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飯沼 宗和
岐阜薬大
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土佐 秀樹
Department Of Pharmacognosy Gifu Pharmaceutical University
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