P-58 グネツム科およびウェルウィッチア科植物のスチルベノイドと生理活性(ポスター発表の部)

概要

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Gnetaceae and Welwitschiaceae are families belonging to the Order Gnetale and several stilbenoids have been reported in the two families. Recent study of stilbenoids has revealed many biological activities such as anticancer, antioxidant and antimicrobial activities. These activities have made stilbenoids to be a potential source of bioactive compounds. In the present study we report on the structure elucidation of five new stilbenoids from the genus of Welwitschia and Gnetum. Amongst which is the first pentamer from the Order Gnetale. The structures of the compounds including the relative stereochemistry were determined by 2D NMR spectroscopy (H-H COSY, NOESY, HMQC and HMBC). Fifty-six stilbenoids from the two families were screened for anticancer and melanin activities. Two compounds (gnemonol G and gnetin I) exhibited anticancer activity against HL 60 cells. Parvifolol A, a stilbene dimer from G. parvifolium, inhibited melanin biosynthesis by down regulation of tyrosinase enzyme expression. Furthermore, the DPPH radical scavenging activity of the stilbenoids and their structural activity relationship were also studied. The result showed that compounds possessing catechol units in their skeleton showed stronger DPPH radical scavenging activity.
2005-09-15