52(P-15) グネツム科植物のスチルベンオリゴマーの構造と生物活性(ポスター発表の部)

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Stilbenoids are a group of phenolic compounds that are drawing interesting attention because of their biological activities such as cancer preventive, anti-inflammatory and blood sugar reducing activities. Gnetum is a genus of tropical plants, distributed in South East Asia, South America and Africa. The plants are mostly used as food as well as medicine. Many stilbenoids in the genus and their various biological activities have been reported. In our previous studies of the gnetaceaeous plants, we reported the stilbenoid constituents in Gnetum parvifolium and their activity against Maillard reaction. In this report we present the phytochemical investigation of four Gnetum. species; G. gnemon, G. gnemonoides, G. africanum. and G. latifolium, from which about 30 new stilbene derivatives were isolated. The stilbene oligomers found in the gnetaceaeous plants are formed by the oxidative coupling of a stilbene monomer such as piceatanol, oxyresveratrol and isorhapontigenin in addition to a resveratrol, which leads to a variety of coupling patterns. Others stilbene oligomers are usually formed by coupling of only resveratrol units. Stilbene glucoside; compounds 1-5 are rare in nature but found in abundantly in Gnetum. FLavonostilbene; compounds 6-11, is the first instance of an oxidative derivative of a flavan-3-ol with a stilbene monomer. Compounds 12 and 13 are the first tetramer to be isolated from the family Gnetaceae for the first time. The structures of these compounds were determined by spectroscopic and chemical evidences. The inhibitory effect of the compounds on lipid protein inhibition and scavenging activity for Super oxide in xanthine-xanthine oxidase system was examined. All the compounds exhibited a moderate antioxidant activity, which supported the importance of the Gnetaceaeous plants as food.
天然有機化合物討論会の論文
2002-09-01

52(P-15) グネツム科植物のスチルベンオリゴマーの構造と生物活性(ポスター発表の部)

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