Identification of QTLs Involved in the Development of Amygdala Kindling in the Rat
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概要
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Amygdala kindling is useful for modeling human epilepsy development. It has been known that genetic factors are involved in the development of amygdala kindling. The purpose of this study was to identify the loci that are responsible for the development of amygdala kindling. To achieve this, rat strains from a LEXF/FXLE recombinant inbred (RI) strain panel were used. The phenotypes of amygdala kindling-related parameters for seven RI strains and parental LE/Stm and F344/Stm strains were determined. They included the afterdischarge threshold (ADT), the afterdischarge duration (ADD), and the kindling rate, an incidence of development of kindling. Quantitative trait loci (QTL) analysis was performed to identify linkage relationships between these phenotypes and 1,033 SNP markers. Although no significant differences in pre-kindling ADT and ADD were observed, a significant difference in the kindling rate was found for the LEXF/FXLE RI strain. Two QTLs for the amygdala kindling rate (Agkr1 and Agkr2) were identified on rat chromosome 2. These findings clearly prove the existence of genetic influences that are involved in kindling development and suggest that substantial genetic components contribute to the progression of partial seizures into generalized seizures.
著者
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Voigt Birger
Institute Of Laboratory Animals Graduate School Of Medicine Kyoto University
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CHIBA Shigeru
Department of Cell Therapy & Transplantation Medicine University of Tokyo Hospital
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Sasa Masashi
Institute Of Laboratory Animals Graduate School Of Medicine Kyoto University
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Serikawa Tadao
Institute For Laboratory Animals Faculty Of Medicine Kyoto University
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HOKAO Ryoji
Institute for Animal Reproduction
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Kuramoto Takashi
Institute Of Laboratory Animals Faculty Of Medicine Kyoto University
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Ishimaru Yuji
Department Of Psychiatry And Neurology Asahikawa Medical College
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Chiba Shigeru
Department of Psychiatry and Neurology, Asahikawa Medical College, 2-1-1-1 Midorigaoka higashi, Asahikawa 078-8510, Japan
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Sasa Masashi
Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
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Kuramoto Takashi
Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
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Hashimoto Ryoko
Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
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Hokao Ryoji
Institute of Animal Reproduction, 1103 Fukaya, Kasumigaura 300-0134, Japan
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Ishimaru Yuji
Department of Psychiatry and Neurology, Asahikawa Medical College, 2-1-1-1 Midorigaoka higashi, Asahikawa 078-8510, Japan
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Voigt Birger
Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
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