A Highly Therapy-Resistant Case of B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma Showing Strong BCL2 Staining, Otherwise Indistinguishable from Burkitt Lymphoma
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概要
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B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma (iDLBCL/BL) is a newly categorized lymphoma in the WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues v4. This lymphoma has characteristics of both DLBCL and BL, morphologically and genetically. We report a case with therapy-resistant iDLBCL/BL, which used to be categorized as BL in the WHO Classification v3. This case showed strong BCL2 staining, otherwise exhibiting features of BL. The case was treated with intensive chemotherapy containing high-dose methotrexate, cyclophosphamide, and cytarabine. However, soon after the chemotherapy, the lymphoma relapsed in the central nervous system and was resistant to whole-brain radiation therapy and allogeneic stem cell transplantation. The patient died 37 days after the transplantation. The clinical course was different from that of typical BL in terms of resistance to intensive chemotherapy, in agreement with the characteristics of iDLBCL/BL. [J Clin Exp Hematopathol 51(1) : 37-42, 2011]
- 2011-05-01
著者
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CHIBA Shigeru
Department of Cell Therapy & Transplantation Medicine University of Tokyo Hospital
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Hasegawa Yuichi
筑波大学医学専門学群附属病院 薬剤部
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Noguchi Masayuki
Departmen Of Pathology Institute Of Clinical Medicine University Of Tsukuba
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Nakamura Naoya
Department Of Otorhinolaryngology Faculty Of Medicine University Of Tokyo
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Okoshi Yasushi
Department Of Clinical And Experimental Hematology Doctoral Program In Advanced Biomedical Applicati
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Yokoyama Yasuhisa
Department Of Physics Faculty Of Science And Technology Sophia University
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Suzukawa Kazumi
Department Of Laboratory Medicine Doctoral Programs In Medical Sciences Graduate School Of Comprehen
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Okoshi Yasushi
Department Of Clinical And Experimental Hematology Graduate School Of Comprehensive Human Sciences U
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Hasegawa Yuichi
Department Of Clinical And Experimental Hematology Graduate School Of Comprehensive Human Sciences U
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Chiba Shigeru
Department Of Clinical And Experimental Hematology Graduate School Of Comprehensive Human Sciences U
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KURITA Naoki
Department of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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NISHIKII Hidekazu
Department of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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NAKAMOTO Rie
Department of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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KONDO Yuzuru
Department of Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Kondo Yuzuru
Department Of Pathology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Nakamoto Rie
Department Of Hematology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Suzukawa Kazumi
Department Of Hematology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Hasegawa Yuichi
Department Of Hematology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Nakamura Naoya
Department Of Hematology Niigata University Graduate School Of Medical And Dental Sciences
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Noguchi Masayuki
Department Of Pathology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Yokoyama Yasuhisa
Department Of Hematology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Noguchi Masayuki
Deparment Of Pathology Institute Of Basic Medical Science University Of Tsukuba
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Nishikii Hidekazu
Department Of Hematology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Okoshi Yasushi
Department Of Clinical And Experimental Hematology Graduate School Of Comprehensive Human Sciences U
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Kurita Naoki
Department Of Hematology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Suzukawa Kazumi
Department of Clinical and Experimental Hematology, Institute of Clinical Medicine, University of Tsukuba
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