A Leukemic Change as an Initial Manifestation of the Common Variant Type of ALK-Positive Anaplastic Large Cell Lymphoma in a Patient with Lung Adenocarcinoma
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概要
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We report an 81-year-old man who had leukemic presentation of ALK-positive anaplastic large cell lymphoma (ALCL) as an initial manifestation. He had been well after chemotherapy and irradiation for the advanced lung adenocarcinoma, but suddenly suffered from severe lactic acidosis and hypotension. The peripheral blood smear and bone marrow aspiration revealed the infiltration of atypical large cells with horseshoe-shaped or lobulated nuclei. The detection of CD30 expression and the t (2;5) (p23;q35) translocation in these cells was confirmatory of a diagnosis of common variant ALK-positive ALCL in a leukemic phase. He deteriorated rapidly and died before administration of the chemotherapy. An adequate, prompt diagnosis is necessary for this rare disease status in oncologic emergency to improve the disease management.
著者
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Asai Satomi
Department Of Laboratory Medicine Tokai University School Of Medicine
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Yabe Miharu
Department Of Cell Transplantation And Laboratory Medicine Tokai University School Of Medicine
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Urano Tetsuya
Department Of Internal Medicine Tokai University School Of Medicine
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Matsushita Hiromichi
Department Of Civil And Structural Engineering Faculty Of Engineering Kyushu University
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Hayama Naoki
Department Of Medicine Tokai University School Of Medicine
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Nakamura Naoya
Department Of Hematology Niigata University Graduate School Of Medical And Dental Sciences
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YABE Miharu
Department of Laboratory Medicine, Tokai University School of Medicine
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MIYACHI HAYATO
Department of Internal Medicine, School of Medicine, Keio University
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Kondo Yusuke
Department Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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Urano Tetsuya
Department of Medicine, Tokai University School of Medicine
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